immune system
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)
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• B cell number particularly B-1 B cells are lower than controls and 3-12 weeks and remain lower at 18-41 weeks of age
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• B-2 cell number is lower than controls at 3-12 weeks of age
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• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
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• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
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hematopoietic system
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)
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• B cell number particularly B-1 B cells are lower than controls and 3-12 weeks and remain lower at 18-41 weeks of age
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• B-2 cell number is lower than controls at 3-12 weeks of age
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• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
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• mature T cells in spleen are reduced in numbers at young age and become comparable to controls at 18-41 weeks of age
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cellular
• in culture, increased cell death in bone marrow pro-B cells is observed compared to controls (increase in sub-G0 population is seen)
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