Phenotypes associated with this allele

• Allele Symbol: Adamts13^tm1Myta
• Allele Name: targeted mutation 1, Toshiyuki Miyata
• Allele ID: MGI:3763820
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts13^tm1Myta/Adamts13^tm1Myta	involves: 129S6/SvEvTac	MGI:3763821

Genotype
MGI:3763821

hm1

• Allelic Composition: Adamts13^tm1Myta/Adamts13^tm1Myta
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet activation ( J:125786 )

• there are about 2-fold more platelet counts in the serum 15 minutes after challenge with collagen and epinephrine

homeostasis/metabolism

abnormal blood coagulation ( J:125786 )

• 29% increase in von Willebrand factor antigen in blood

• 46% increase in FVIII activity in the blood

abnormal platelet activation ( J:125786 )

• there are about 2-fold more platelet counts in the serum 15 minutes after challenge with collagen and epinephrine

abnormal thrombosis ( J:125786 )

• thrombus volume is increased when blood is perfused for 5 minutes over a collagen coated surface