Phenotypes associated with this allele

• Allele Symbol: Traip^tm1Jarh
• Allele Name: targeted mutation 1, Jaerang Rho
• Allele ID: MGI:3764469
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traip^tm1Jarh/Traip^tm1Jarh	involves: C57BL/6J	MGI:3764472

Genotype
MGI:3764472

hm1

• Allelic Composition: Traip^tm1Jarh/Traip^tm1Jarh
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:127324 )

• no embryos are present at E8.5 and all those recovered at E7.5 are abnormal

embryo

increased embryonic tissue cell apoptosis ( J:127324 )

• at E6.5 and E7.5, elevated numbers of apoptotic cells are scattered throughout the embryo compared to wild-type embryos

embryonic growth retardation ( J:127324 )

• at E5.5, embryos display an abnormal egg cylinder indicating growth retardation that is also observed at E7.5

decreased embryo size ( J:127324 )

• at E5.5

• at E7.5, embryonic and extra-embryonic regions are smaller and reduced in cell number compared to wild-type mice

abnormal embryonic tissue morphology ( J:127324 )

• at E6.5, mice exhibit a substantial loss of embryonic tissue

• at E7.5, only traces of the tissue formed during gastrulation can be observed

absent proamniotic cavity ( J:127324 )

• at E6.5, the proamniotic cavity is absent

cellular

increased embryonic tissue cell apoptosis ( J:127324 )

• at E6.5 and E7.5, elevated numbers of apoptotic cells are scattered throughout the embryo compared to wild-type embryos

decreased cell proliferation ( J:127324 )

• at E6.5 and E7.5, cell proliferation is less in the whole embryo than in wild-type mice

growth/size/body

embryonic growth retardation ( J:127324 )

• at E5.5, embryos display an abnormal egg cylinder indicating growth retardation that is also observed at E7.5

decreased embryo size ( J:127324 )

• at E5.5

• at E7.5, embryonic and extra-embryonic regions are smaller and reduced in cell number compared to wild-type mice