Phenotypes associated with this allele

• Allele Symbol: Pcdh10^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3764488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcdh10^tm1Lex/Pcdh10^tm1Lex	involves: C57BL/6N	MGI:3764490

Genotype
MGI:3764490

hm1

• Allelic Composition: Pcdh10^tm1Lex/Pcdh10^tm1Lex
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:127418 )

• mice die within several weeks of unknown causes

nervous system

abnormal brain morphology ( J:127418 )

• mice lack the cerebral peduncle and the corticospinal tract

• the corticofugal axons halt at the ventral telencephalon

abnormal telencephalon morphology ( J:127418 )

• thalamocortical axons enter the ventral telencephalon are disorganized and most do not reach the normal internal capsule but are dispersed broadly within the ventral telencephalon

• Nkx2.1 and Islet-1 expression denoting the cells of the thalamocortical tract and corridor are absent from the caudal part of the ventral telecephalon at E13.5

• however, the globus pallidus is present and no increase in apoptosis is observed

• guide-post cells (DiI+) in the internal capsule region of the ventral telencephalon are largely absent

• striatal cells are gathered together irregularly following elongation at E13.5 trapping thalamocortical axons

• at E13.5, striatal and thalamocortical axons fail to project into the diencephalic-telecephalic boundary

• the striatonigral tract is absent

• however, tyrosine-hydrolase expressing nigrostriatal projections into the ventral telecephalon are normal

growth/size/body

decreased body size ( J:127418 )

• at birth mice are smaller than heterozygotes and the difference becomes more pronounced a few weeks after birth