mortality/aging
• Background Sensitivity: embryonic lethal with 100% penetrance in 129S4 congenic background compared to B6 congenic or mixed B6-129 background, timing of death was not stated
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Allele Symbol Allele Name Allele ID |
Fn1tm4Hyn targeted mutation 4, Richard Hynes MGI:3764511 |
Summary |
3 genotypes |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: embryonic lethal with 100% penetrance in 129S4 congenic background compared to B6 congenic or mixed B6-129 background, timing of death was not stated
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: embryonic lethal with about 50% penetrance in B6 congenic background compared to 129 congenic or mixed B6-129 background, timing of death was not stated
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: embryonic lethal with about 80% penetrance, 50% of E9.5 and 80% of E10.5 mutant embryos showed severe cardiovascular defects and were absorbed by E11.0 in mixed background compared to congenic strain of 129 or B6
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• placental vascularization following the invasion with embryonic vessels was much less extensive in about 50% of mutant embryos
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• in severely affected mutant E9.5 embryos, dysmorphic large vessels in the head and small vessels in the head and body appeared syncytial with endothelial cells forming sheets instead of tubes
• in less severely affected, abnormally patterned, blunt-ended and constricted head veins
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• in some embryos with blistered yolk sac
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• in some embryos with blistered yolk sac
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• a decrease in the number of vascular smooth muscle cells in E10.5 embryos
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• thinned outflow tract in 30% of all defective embryos by E10.5
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• in some abnormal E10.5 embryos
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• in 50% of all defective embryos by E10.5
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• within the 83% of all defective embryos by E9.5 and 100% by E10.5
• focal head hemorrhage in a small number of morphologically normal E10.5 embryos
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• shortened posterior, kinked neural tube in 5% of all defective embryos by E9.5
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• placental vascularization following the invasion with embryonic vessels was much less extensive in about 50% of mutant embryos
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• in some embryos with blistered yolk sac
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• shortened posterior, kinked neural tube in 5% of all defective embryos by E9.5
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• separation of endodermal and mesodermal layer resulting in blistered appearance of the yolk sac in 30% of all defective embryos by E9.5
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• in some embryos with blistered yolk sac
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• in some embryos with blistered yolk sac
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• a decrease in the number of vascular smooth muscle cells in E10.5 embryos
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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