Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Lta)#Flv
• Allele Name: transgene insertion #, Richard Flavell
• Allele ID: MGI:3764659
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-Lta)#Flv/0	involves: C57BL/6	MGI:3765991
tg2	Tg(Ins2-Lta)#Flv/0	involves: C57BL/6 * CBA	MGI:3766083
tg3	Tg(Ins2-Lta)#Flv/0	involves: NOD	MGI:3765990

Genotype
MGI:3765991

tg1

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all transgenic mice, while controls and Tnf-transgenic mice do not display this

renal/urinary system

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all transgenic mice, while controls and Tnf-transgenic mice do not display this

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91820 )

• less islets (60-65%) display infiltrating mononuclear cells than Tnf-transgenic mice (100%) at 5 months of age

insulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to C57BL/6 mice display mixed periinsulitis and insulitis

Genotype
MGI:3766083

tg2

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: C57BL/6 * CBA

Mononuclear cell infiltration in islets of Tg(Ins2-Lta)#Flv/0 mice

immune system

insulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets are partially or completely infiltrated with mononuclear cells

• 30-45% of islets in mice 1-5 months of age do not have apparent infiltration

• ~10% of islets show insulitis or periinsulitis in 1 month old mice, with 30-45% of islets affected in 5-month old animals

periinsulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets show interstitial accumulation of mononuclear cells around the islet capsule without obvious infiltration

endocrine/exocrine glands

insulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets are partially or completely infiltrated with mononuclear cells

• 30-45% of islets in mice 1-5 months of age do not have apparent infiltration

• ~10% of islets show insulitis or periinsulitis in 1 month old mice, with 30-45% of islets affected in 5-month old animals

periinsulitis ( J:127705 )

• apparent in transgenic animals, but not in non-transgenic littermates; some islets show interstitial accumulation of mononuclear cells around the islet capsule without obvious infiltration

Genotype
MGI:3765990

tg3

• Allelic Composition: Tg(Ins2-Lta)#Flv/0
• Genetic Background: involves: NOD

immune system

insulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all F1 offspring from crosses to NOD mice mice, while controls and Tnf-transgenic mice do not display this

renal/urinary system

kidney inflammation ( J:91820 )

• focal infiltration of mononuclear cells is observed in all F1 offspring from crosses to NOD mice mice, while controls and Tnf-transgenic mice do not display this

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91820 )

• less islets (60-65%) display infiltrating mononuclear cells than Tnf-transgenic mice from F1 crosses to NOD mice (seen in 100% of animals) at 5 months of age

• in prediabetic mice, CD4+ and CD8+ T cells represent 50% of infiltrating cells in islets; the other 50% are CD4/CD8 double negative cells

insulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis

periinsulitis ( J:91820 )

• F1 offspring from crosses to NOD mice display mixed periinsulitis and insulitis