digestive/alimentary system
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• one week after tamoxifen administration, 56% of mutant crypts show stem cells forming a clustering pattern lacking clear demarcation between each other, while at 3 weeks after tamoxifen administration, 85% do so
• stem cells in mutant crypts 3 weeks after tamoxifen treatment lose the typical triangle shapes and marker analysis indicates disrupted crypt cell polarity
• loss of stem cells
• intestinal crypt cells, most likely Paneth cells, contain large vacuoles
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• reduction or absence of Paneth cell granules, indicating loss of Paneth cells
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endocrine/exocrine glands
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• one week after tamoxifen administration, 56% of mutant crypts show stem cells forming a clustering pattern lacking clear demarcation between each other, while at 3 weeks after tamoxifen administration, 85% do so
• stem cells in mutant crypts 3 weeks after tamoxifen treatment lose the typical triangle shapes and marker analysis indicates disrupted crypt cell polarity
• loss of stem cells
• intestinal crypt cells, most likely Paneth cells, contain large vacuoles
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• reduction or absence of Paneth cell granules, indicating loss of Paneth cells
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