Phenotypes associated with this allele

• Allele Symbol: Bnip3^tm1Gwd
• Allele Name: targeted mutation 1, Gerald W Dorn II
• Allele ID: MGI:3764664
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bnip3^tm1Gwd/Bnip3^tm1Gwd	Not Specified	MGI:3764674

Genotype
MGI:3764674

hm1

• Allelic Composition: Bnip3^tm1Gwd/Bnip3^tm1Gwd
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:127533 )

N • heart morphology and function are the same as wild-type under non-stressed conditions

abnormal response of heart to induced stress ( J:127533 )

• 2 days after ischemic reperfusion, peri-infarct and remote myocyte apoptosis is decreased by half compared to in wild-type mice

• following ischemic assault, end volume systolic volume is only increased 35+/-20% compared to an increase of 181+/-41% in wild-type mice, sphericity is unchanged, ejection fraction is stable

• post-ischemic ventricular remodeling is decreased compared to in wild-type mice

• infarct scar thickness is greater than in wild-type mice

• however, infarct size is similar to in wild-type mice

• remote myocardial contraction is better post-ischemia than in wild-type mice (-12.2+/-1.0 compared to -8.9+/-0.6 in wild-type mice)

muscle

decreased cardiomyocyte apoptosis ( J:127533 )

• 2 days after ischemic reperfusion, peri-infarct and remote myocyte apoptosis is decreased by half compared to in wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:127533 )

N • circulating red and white blood cells and platelet counts are normal

homeostasis/metabolism

abnormal response of heart to induced stress ( J:127533 )

• 2 days after ischemic reperfusion, peri-infarct and remote myocyte apoptosis is decreased by half compared to in wild-type mice

• following ischemic assault, end volume systolic volume is only increased 35+/-20% compared to an increase of 181+/-41% in wild-type mice, sphericity is unchanged, ejection fraction is stable

• post-ischemic ventricular remodeling is decreased compared to in wild-type mice

• infarct scar thickness is greater than in wild-type mice

• however, infarct size is similar to in wild-type mice

• remote myocardial contraction is better post-ischemia than in wild-type mice (-12.2+/-1.0 compared to -8.9+/-0.6 in wild-type mice)

cellular

decreased cardiomyocyte apoptosis ( J:127533 )

• 2 days after ischemic reperfusion, peri-infarct and remote myocyte apoptosis is decreased by half compared to in wild-type mice