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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ripply2tm1Asas
targeted mutation 1, Makoto Asashima
MGI:3764703
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ripply2tm1Asas/Ripply2tm1Asas involves: C57BL/6 * CBA MGI:3764704


Genotype
MGI:3764704
hm1
Allelic
Composition
Ripply2tm1Asas/Ripply2tm1Asas
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply2tm1Asas mutation (1 available); any Ripply2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die shortly after birth without breathing

respiratory system
• fail to breath after birth

embryo
• expression analysis indicates that rostrocaudal polarity is disrupted
• considerable truncation at E18
• at E11.5 segmentation is absent in the caudal portion of homozygous embryos

skeleton
N
• despite abnormalities in the axial skeleton, limb and skull morphology appear normal and no abnormalities in osteogenesis are detected
• at E18, rib pair number is reduced to 9 compared to 13 pairs in wild-type littermates
• at E18
• at E18
• at E18 the metameric pattern of the vertebral bodies, intervertebral discs and neural arches is severely disrupted
• the pedicles of neural arches are fused or missing at E18

growth/size/body
• severely reduced in size at E18

limbs/digits/tail
• visible at E18

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spondylocostal dysostosis DOID:0050568 OMIM:PS277300
J:122747





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory