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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr2e1tm2Gsc
targeted mutation 2, Gunther Schutz
MGI:3764730
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nr2e1tm2Gsc/Nr2e1tm2Gsc
Tg(Camk2a-cre)2Gsc/?
involves: C57BL/6 * FVB/N * SJL MGI:3764808


Genotype
MGI:3764808
cn1
Allelic
Composition
Nr2e1tm2Gsc/Nr2e1tm2Gsc
Tg(Camk2a-cre)2Gsc/?
Genetic
Background
involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm2Gsc mutation (0 available); any Nr2e1 mutation (32 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

behavior/neurological
N
• mice display normal contextual, associative and spatial learning unlike germline null Nr2e1 mice
• mice are hyperaggressive and attack other mice despite their small size
• mice display less anxiety-related behaviors in a dark light box test in which they spend more time in the lit compartment, enter into the light compartment more often and enter the lit compartment sooner than wild-type mice

growth/size/body

vision/eye
N
• eye morphology and physiology are normal unlike germline null Nr2e1 mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory