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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdf3Gt(AD0857)Wtsi
gene trap AD0857, Wellcome Trust Sanger Institute
MGI:3764814
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:3764835
cx2
 		Gdf1tm1Sjl/Gdf1+
Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3764837
cx3
 		Gdf1tm1Sjl/Gdf1+
Gdf3Gt(AD0857)Wtsi/Gdf3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3764838
cx4
 		Gdf1tm1Sjl/Gdf1tm1Sjl
Gdf3Gt(AD0857)Wtsi/Gdf3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3764839
cx5
 		Gdf1tm1Sjl/Gdf1tm1Sjl
Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi 		involves: 129P2/OlaHsd * C57BL/6 MGI:3764836


Genotype
MGI:3764835
hm1
Allelic
Composition		 Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf3Gt(AD0857)Wtsi mutation (0 available); any Gdf3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:127541 )
• 50% of mice survive into adulthood
embryonic lethality between implantation and somite formation, incomplete penetrance ( J:127541 )
• 50% of embryos die by this stage with the remaining 50% surviving into adulthood

embryo
abnormal anterior visceral endoderm cell migration ( J:127541 )
• 31% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo
rostral body truncation ( J:127541 )
• affected embryos display anterior truncations or more severe body plan defects at E8.5
absent mesoderm ( J:127541 )
• 4% of E7.5 embryos lack a mesoderm as determined by an absence of FoxA2 staining
abnormal primitive streak formation ( J:127541 )
• 26% of E7.5 embryos display defects in primitive streak elongation with some embryos displaying two primitive streaks
abnormal primitive streak elongation ( J:127541 )
• 26% of E7.5 embryos display defects in primitive streak elongation
absent anterior visceral endoderm ( J:127541 )
• 15% of E6.5 embryos fail to develop the anterior visceral endoderm (AVE)

cellular
abnormal anterior visceral endoderm cell migration ( J:127541 )
• 31% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo




Genotype
MGI:3764837
cx2
Allelic
Composition		 Gdf1tm1Sjl/Gdf1+
Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Gdf3Gt(AD0857)Wtsi mutation (0 available); any Gdf3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:127541 )
• 50% of mice survive into adulthood
embryonic lethality between implantation and somite formation, incomplete penetrance ( J:127541 )
• 50% of embryos die by this stage with the remaining 50% surviving into adulthood

embryo
abnormal anterior visceral endoderm cell migration ( J:127541 )
• 30% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo
absent mesoderm ( J:127541 )
• 18% of E7.5 embryos lack a mesoderm as determined by an absence of FoxA2 staining
abnormal primitive streak formation ( J:127541 )
• 30% of E7.5 embryos display defects in primitive streak elongation with some embryos displaying two primitive streaks
abnormal primitive streak elongation ( J:127541 )
• 30% of E7.5 embryos display defects in primitive streak elongation
absent anterior visceral endoderm ( J:127541 )
• 15% of E6.5 embryos fail to develop the anterior visceral endoderm (AVE)

cellular
abnormal anterior visceral endoderm cell migration ( J:127541 )
• 30% of E6.5 embryos develop AVE distally but the tissue fails to migrate to the anterior side of the pregastrulation embryo




Genotype
MGI:3764838
cx3
Allelic
Composition		 Gdf1tm1Sjl/Gdf1+
Gdf3Gt(AD0857)Wtsi/Gdf3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Gdf3Gt(AD0857)Wtsi mutation (0 available); any Gdf3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3764839
cx4
Allelic
Composition		 Gdf1tm1Sjl/Gdf1tm1Sjl
Gdf3Gt(AD0857)Wtsi/Gdf3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Gdf3Gt(AD0857)Wtsi mutation (0 available); any Gdf3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3764836
cx5
Allelic
Composition		 Gdf1tm1Sjl/Gdf1tm1Sjl
Gdf3Gt(AD0857)Wtsi/Gdf3Gt(AD0857)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf1tm1Sjl mutation (1 available); any Gdf1 mutation (8 available)
Gdf3Gt(AD0857)Wtsi mutation (0 available); any Gdf3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:127541 )
• 50% of mice survive into adulthood
embryonic lethality between implantation and somite formation, incomplete penetrance ( J:127541 )
• 50% of embryos die by this stage with the remaining 50% surviving until adulthood

embryo
absent mesoderm ( J:127541 )
• 47% of E7.5 embryos lack a mesoderm as determined by an absence of FoxA2 staining
abnormal primitive streak formation ( J:127541 )
• 26% of E7.5 embryos display defects in primitive streak elongation with some embryos displaying two primitive streaks
abnormal primitive streak elongation ( J:127541 )
• 26% of E7.5 embryos display defects in primitive streak elongation
absent anterior visceral endoderm ( J:127541 )
• 38% of E6.5 embryos fail to develop the anterior visceral endoderm (AVE)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory