All Phenotypes Trpc1<tm1Lbi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trpc1^tm1Lbi
targeted mutation 1, Lutz Birnbaumer
MGI:3764882

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc1^tm1Lbi/Trpc1^tm1Lbi	involves: 129S/SvEv	MGI:3764888
hm2	Trpc1^tm1Lbi/Trpc1^tm1Lbi	involves: 129S/SvEv * C57BL/6	MGI:5474576
hm3	Trpc1^tm1Lbi/Trpc1^tm1Lbi	involves: 129S/SvEv * C57BL/6J	MGI:3765000
cx4	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni	involves: 129 * C57BL/6	MGI:5474577
cx5	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:3810159
cx6	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni Trpc6^tm1Lbi/Trpc6^tm1Lbi	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:3810160

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1^tm1Lbi mutation (1 available); any Trpc1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal submandibular gland physiology ( J:127118 )

• carbachol or thapsigarin stimulated Ca²⁺ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells

• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls

endocrine/exocrine glands

abnormal submandibular gland physiology ( J:127118 )

• carbachol or thapsigarin stimulated Ca²⁺ entry into submandibular gland acinar cells is reduced by over 60% compared to wild-type control cells

• both inward and outward store-operated cation currents are severely reduced in submandibular gland acinar cells

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls

nervous system

nervous system phenotype ( J:139695 )

N	• normal mGluR1 (Grm1) mediated synaptic transmission • normal slow EPSC

homeostasis/metabolism

decreased salivation ( J:127118 )

• saliva secretion and flow are severely reduced after parasympathetic stimulation with pilocarpine

• however, submandibular gland morphology and size are similar to wild-type controls

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1^tm1Lbi mutation (1 available); any Trpc1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal single cell response ( J:194590 )

• in pyramidal neurons from the CA1 region (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induced bursts are retarded with reduced plateau amplitudes and spike numbers per burst

behavior/neurological

behavior/neurological phenotype ( J:194590 )

N	• severity of pilocarpine induced seizures is similar to controls

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1^tm1Lbi mutation (1 available); any Trpc1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:127788 )

N	• despite expression and activity results from previous studies and in other species no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells

growth/size/body

increased body size ( J:127788 )

increased body weight ( J:127788 )

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc1^tm1Lbi mutation (1 available); any Trpc1 mutation (41 available)
Trpc4^tm1Bni mutation (0 available); any Trpc4 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal single cell response ( J:194590 )

• in pyramidal neurons from the CA1 region (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid induced bursts are retarded with reduced plateau amplitudes and spike numbers per burst

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139695 )

N	• normal mGluR1 (Grm1) mediated synaptic transmission • normal slow EPSC

Allelic Composition	Trpc1^tm1Lbi/Trpc1^tm1Lbi Trpc4^tm1Bni/Trpc4^tm1Bni Trpc6^tm1Lbi/Trpc6^tm1Lbi
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139695 )

N	• normal mGluR1 (Grm1) mediated synaptic transmission • normal slow EPSC

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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