About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm3aGt(YHA186)Byg
gene trap YHA186, BayGenomics
MGI:3764891
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg involves: 129P2/OlaHsd MGI:3840233
hm2
 		Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3764912


Genotype
MGI:3840233
hm1
Allelic
Composition		 Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3aGt(YHA186)Byg mutation (0 available); any Kdm3a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:147295 )




Genotype
MGI:3764912
hm2
Allelic
Composition		 Kdm3aGt(YHA186)Byg/Kdm3aGt(YHA186)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3aGt(YHA186)Byg mutation (0 available); any Kdm3a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:127121 )
N
• no significant alterations in follicular stimulating hormone, lutenizing hormone, androstenedione, or testosterone levels are detected
asthenozoospermia ( J:127121 )
• despite the presence of tails on all sperm, 98.5% are immotile
abnormal seminiferous tubule morphology ( J:127121 )
• multiple vacuolations present
• however, the morphology of Sertoli and Leydig cells is normal
abnormal sperm head morphology ( J:127121 )
• all epididymal sperm have abnormally shaped heads
abnormal acrosome assembly ( J:127121 )
• although the acrosomal structure appears normal in round spermatids at step 7, it is not fully formed at step 13
abnormal spermatid morphology ( J:127121 )
• fewer elongated spermatids present
• at stage 8 multiple spermatids sharing cytoplasm and with multiple tails are presen
• at stage 11 - 12 spermatids have heads that are not as elongated as in wild-type mice
abnormal spermiogenesis ( J:127121 )
• elongation of spermatids, spermatid separation, and acrosomal formation are impaired
• chromocentre organization of the nucleus and polarity of chromatin distribution are absent
• abnormalities are confined to post-meiotic stages of spermatogenesis
• chromatin condensation is disrupted

cellular
abnormal sperm head morphology ( J:127121 )
• all epididymal sperm have abnormally shaped heads
abnormal acrosome assembly ( J:127121 )
• although the acrosomal structure appears normal in round spermatids at step 7, it is not fully formed at step 13
abnormal spermatid morphology ( J:127121 )
• fewer elongated spermatids present
• at stage 8 multiple spermatids sharing cytoplasm and with multiple tails are presen
• at stage 11 - 12 spermatids have heads that are not as elongated as in wild-type mice
asthenozoospermia ( J:127121 )
• despite the presence of tails on all sperm, 98.5% are immotile

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:127121 )
• multiple vacuolations present
• however, the morphology of Sertoli and Leydig cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory