Phenotypes associated with this allele

• Allele Symbol: Ptger1^tm1Matb
• Allele Name: targeted mutation 1, Matthew D Breyer
• Allele ID: MGI:3764892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptger1^tm1Matb/Ptger1^tm1Matb	129S6/SvEvTac-Ptger1^tm1Matb	MGI:3764909

Genotype
MGI:3764909

hm1

• Allelic Composition: Ptger1^tm1Matb/Ptger1^tm1Matb
• Genetic Background: 129S6/SvEvTac-Ptger1^tm1Matb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:127410 )

• angiotension II -associated cardiac hypertrophy was significantly reduced by 13%

decreased mean systemic arterial blood pressure ( J:127410 )

• arterial blood pressure levels are reduced by 1.25 fold during angiotensin II infusion and more than 2 fold for other prostaglandin receptor agonists

decreased systemic arterial systolic blood pressure ( J:127410 )

• baseline systolic blood pressure is reduced by about 10 % compared to wild-type mice

• with long term angiotensin II infusion, the systolic blood pressure averaged 16 mmHg less than in wild-type controls

increased mean systemic arterial blood pressure ( J:127410 )

• arterial blood pressure levels are higher than in wild-type controls when infused with vasodepressors

renal/urinary system

decreased urine sodium level ( J:127410 )

• sodium excretion following a switch from a low- to high- sodium diet is reduced

oliguria ( J:127410 )

• volume of urine excreted is decreased by 40% following a switch from a low- to high- sodium diet is significantly reduced

behavior/neurological

decreased fluid intake ( J:127410 )

• mice drink about 40% less water following a switch from a low- to high- sodium diet

decreased food intake ( J:127410 )

• mice consume reduced amounts of food following a switch from a low- to high- sodium diet

homeostasis/metabolism

decreased urine sodium level ( J:127410 )

• sodium excretion following a switch from a low- to high- sodium diet is reduced

growth/size/body

cardiac hypertrophy ( J:127410 )

• angiotension II -associated cardiac hypertrophy was significantly reduced by 13%