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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GUSB)4Sly
transgene insertion 4, William S Sly
MGI:3764916
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gusbmps/Gusbmps
Tg(GUSB)4Sly/Tg(GUSB)4Sly 		involves: C57BL/6By * C57BL/6J * LT/Sv * SJL/J MGI:3784507


Genotype
MGI:3784507
cx1
Allelic
Composition		 Gusbmps/Gusbmps
Tg(GUSB)4Sly/Tg(GUSB)4Sly
Genetic
Background		 involves: C57BL/6By * C57BL/6J * LT/Sv * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gusbmps mutation (8 available); any Gusb mutation (44 available)
Tg(GUSB)4Sly mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lysosomal storage disease is evident in Gusbmps/Gusbmps mice and is rescued by Tg(GUSB)4Sly/Tg(GUSB)4Sly expression

normal phenotype
no abnormal phenotype detected ( J:21256 )
• mutant mice appear phenotypically normal; transgene expression rescues the lysosomal enzyme elevation, glycosaminoglycan storage, dwarfism, abnormal gait, limited joint mobility, skeletal deformities, and paucity of adipose tissue that are seen in Gusb homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory