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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabrg2tm1Spet
targeted mutation 1, Steven Petrou
MGI:3764923
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabrg2tm1Spet/Gabrg2tm1Spet involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3764956
ht2
 		Gabrg2tm1Spet/Gabrg2+ involves: 129 * BALB/cJ * C57BL/6 * DBA/2J MGI:3764958
ht3
 		Gabrg2tm1Spet/Gabrg2+ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ MGI:5474682
ht4
 		Gabrg2tm1Spet/Gabrg2+ involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3764957
cx5
 		Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J 		B6.129(Cg)-Gabrg2tm1Spet/Frk MGI:6511091
cx6
 		Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0 		B6.129(Cg)-Gabrg2tm1Spet Tg(n-TRtct5)574Slac MGI:6511097


Genotype
MGI:3764956
hm1
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:127120 )
• mice that are born die before P19

behavior/neurological
tremors ( J:127120 )
• mice that are born exhibit a severe tremor
abnormal gait ( J:127120 )
• mice that are born have altered gaits

nervous system
abnormal brain wave pattern ( J:127120 )
• mice lack normal brain rhythms




Genotype
MGI:3764958
ht2
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absence seizures ( J:127120 )
• Background Sensitivity: more mice (greater than 90%) exhibit symptomatic spike-wave discharge (SWD) on a DBA/2J background than on a C57BL/6 background with longer SWD episodes (2.53+/-0.21 ms compared to 1.20+/-0.16 ms on a C57BL/6 background)
• Background Sensitivity: paroxysmal discharges are first noted at P20, by P22 amplitudes of the sharp waves are increased with associated behavioral arrest and frank epileptiform discharges occur by P24 to P28 with distinct spikes and wave morphology associated with behavioral arrest
• treatment with ethosuximide (200 mg per kg) reduces absence seizure
abnormal inhibitory postsynaptic currents ( J:127120 )
• miniature inhibitory postsynaptic current amplitudes of cortical neurons are lower than in wild-type mice (57.9+/-2.9 pA compared to 66.4+/-1.8 pA in wild-type mice)
• however, spontaneous inhibitory postsynaptic currents in the thalamic reticular nuclei are normal

behavior/neurological
absence seizures ( J:127120 )
• Background Sensitivity: more mice (greater than 90%) exhibit symptomatic spike-wave discharge (SWD) on a DBA/2J background than on a C57BL/6 background with longer SWD episodes (2.53+/-0.21 ms compared to 1.20+/-0.16 ms on a C57BL/6 background)
• Background Sensitivity: paroxysmal discharges are first noted at P20, by P22 amplitudes of the sharp waves are increased with associated behavioral arrest and frank epileptiform discharges occur by P24 to P28 with distinct spikes and wave morphology associated with behavioral arrest
• treatment with ethosuximide (200 mg per kg) reduces absence seizure




Genotype
MGI:5474682
ht3
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

nervous system




Genotype
MGI:3764957
ht4
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to pharmacologically induced seizures ( J:127120 )
• mice are more sensitive to seizures induced with 85 mg per kg pentylenetetrazol than wild-type mice
absence seizures ( J:127120 )
• when stimulated with 5 and 8 Hz and high-amplitude (500 to 1100 uV) spike-wave discharge (SWD) is observed up to 50 times an hour
• during SWD mice pause and display stereotypical nodding and twitching of the orofacial region with some mice exhibiting subtle head jerk or turn that are not observed in wild-type mice
• Background Sensitivity: fewer mice exhibit symptomatic spike-wave discharge (SWD) on a C57BL/6 background than on a DBA/2J background with shorter SWD episodes (1.20+/-0.16 ms compared to 2.53+/-0.21 ms on DBA/2J background)
abnormal inhibitory postsynaptic currents ( J:127120 )
• miniature inhibitory postsynaptic current amplitudes of cortical neurons are lower than in wild-type mice (58.4+/-2.2 pA compared to 67.5+/-2.9 pA in wild-type mice)
• however, spontaneous inhibitory postsynaptic currents in the thalamic reticular nuclei are normal

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:127120 )
• mice are more sensitive to seizures induced with 85 mg per kg pentylenetetrazol than wild-type mice
absence seizures ( J:127120 )
• when stimulated with 5 and 8 Hz and high-amplitude (500 to 1100 uV) spike-wave discharge (SWD) is observed up to 50 times an hour
• during SWD mice pause and display stereotypical nodding and twitching of the orofacial region with some mice exhibiting subtle head jerk or turn that are not observed in wild-type mice
• Background Sensitivity: fewer mice exhibit symptomatic spike-wave discharge (SWD) on a C57BL/6 background than on a DBA/2J background with shorter SWD episodes (1.20+/-0.16 ms compared to 2.53+/-0.21 ms on DBA/2J background)




Genotype
MGI:6511091
cx5
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 B6.129(Cg)-Gabrg2tm1Spet/Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:297745 )
• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)

nervous system
abnormal spike wave discharge ( J:297745 )
• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)




Genotype
MGI:6511097
cx6
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0
Genetic
Background		 B6.129(Cg)-Gabrg2tm1Spet Tg(n-TRtct5)574Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct5)574Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:297745 )
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)

nervous system
abnormal spike wave discharge ( J:297745 )
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory