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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apctm1.1Tno
targeted mutation 1.1, Tetsuo Noda
MGI:3764940
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Apctm1.1Tno/Apc+ involves: 129S4/SvJae * C57BL/6 MGI:3764960
ht2
Apctm1.1Tno/Apctm1Tno involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6 MGI:4429569
cx3
Apctm1.1Tno/Apc+
Ctnna1del/Ctnna1+
involves: 129S4/SvJae * C57BL/6 MGI:3764961


Genotype
MGI:3764960
ht1
Allelic
Composition
Apctm1.1Tno/Apc+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1.1Tno mutation (0 available); any Apc mutation (158 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average lifespan is 22.5 weeks due to bowel obstructions and bleeding

neoplasm
• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine

digestive/alimentary system
• severe bleeding often is cause of death
• 7 to 50 fold more small intestine tumors as in wild-type controls, with the higher incidences occurring in the more distal portions of the small intestine
• occurring frequently in the jejunum and ileum
• resulting from the numerous polyps in the small intestines
• major cause of death by 22.5 weeks of age

hematopoietic system
• resulting from intestinal bleeding

cardiovascular system
• severe bleeding often is cause of death




Genotype
MGI:4429569
ht2
Allelic
Composition
Apctm1.1Tno/Apctm1Tno
Genetic
Background
involves: 129 * 129S4/SvJae * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1.1Tno mutation (0 available); any Apc mutation (158 available)
Apctm1Tno mutation (6 available); any Apc mutation (158 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mutant mice found at birth

nervous system
• embryos lack all structures anterior to the hindbrain at embryonic day 9.5 (E9.5), E12 and E16

craniofacial
• a prominent cap of neural tissue at the most anterior part of the embryo at E12
• absent mandible at E12
• a prominent cap of neural tissue at the most anterior part of the embryo at E12
• absent cranial structures at E12

skeleton
• a prominent cap of neural tissue at the most anterior part of the embryo at E12
• absent mandible at E12
• a prominent cap of neural tissue at the most anterior part of the embryo at E12
• absent cranial structures at E12




Genotype
MGI:3764961
cx3
Allelic
Composition
Apctm1.1Tno/Apc+
Ctnna1del/Ctnna1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1.1Tno mutation (0 available); any Apc mutation (158 available)
Ctnna1del mutation (0 available); any Ctnna1 mutation (133 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• the tumorigenic phenotype associated with the Apctm1.1Tno allele does not occur when both alleles are in a cis-configuration





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory