Analysis Tools
reproductive system
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• at 3 weeks, the anogenital distance is reduced in males compared to wild-type males
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• seminal vesicle weight is less than in wild-type mice (33.2+/-4.7 mg compared to 272.2+/-22.6 mg)
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small ovary
(
J:127450
)
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• smaller than wild-type controls
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• ovary weight is decreased (7.5+/-0.7 mg compared to 19.9+/-0.9 mg)
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small testis
(
J:127450
)
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• smaller than wild-type controls
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• testis weigh less than in wild-type mice (9.0+/-1.7 mg compared to 243.6+/-9.7 mg)
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small penis
(
J:124098
)
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• penis weight is less than in wild-type mice (19.5+/-2.0 mg compared to 52.5+/-6.1 mg)
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infertility
(
J:124098
)
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• paired mice are infertile
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• after a 45 minute period of testing no males ejaculate compared to 40% of wild-type males
• testosterone treatment increases the percent of mice ejaculating to 17%
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behavior/neurological
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• males do not display sexual behaviors
• male mice treated with testosterone exhibit more thrusts, but not intromission bouts, than treated wild-type males
• males have no olfactory preference for estrous females even when treated with testosterone
• however, treatment with testosterone restores sexual behavior in 80% of males
• however, female sexual behavior is normal
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homeostasis/metabolism
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• plasma luteinizing hormone (LH) level is reduced in males (0.05+/-0.1 ng/ml compared to 1.19+/-0.61 ng/ml)
(J:124098)
• levels of LH are not increased by treatment with kisspeptin
(J:124098)
• no surge in luteinizing hormone levels occurred after kisspeptin treatment or ovariectomy
(J:127450)
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• levels of luteinizing hormone are not increased by treatment with kisspeptin
• treatment with testosterone restores some sexual behavior (thrusts) but not others (olfactory preference, ejaculation)
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nervous system
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• male mice have increased numbers of TH+ neurons in the anteroventral periventricular nucleus (AVPV) of the hypothalamus compared to wild-type males
• male mice have more Kiss1+ neurons in the AVPV than in wild-type mice
• however, there is no difference in the number of Kiss1+ neurons in regions that are not sexually dimorphic
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• testosterone treated males have 50% fewer spinal nucleus of the bulbocavernosus (SNB) than testosterone treated wild-type male but similar to the amount of SNBs found in wild-type and null females
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growth/size/body
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• adult males weigh less than wild-type mice (25.1+/-1.0 g compared to 28.0+/-1.0 g)
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digestive/alimentary system
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• at 3 weeks, the anogenital distance is reduced in males compared to wild-type males
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renal/urinary system
small penis
(
J:124098
)
|
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• penis weight is less than in wild-type mice (19.5+/-2.0 mg compared to 52.5+/-6.1 mg)
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endocrine/exocrine glands
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• seminal vesicle weight is less than in wild-type mice (33.2+/-4.7 mg compared to 272.2+/-22.6 mg)
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small ovary
(
J:127450
)
|
|
• smaller than wild-type controls
|
|
|
• ovary weight is decreased (7.5+/-0.7 mg compared to 19.9+/-0.9 mg)
|
small testis
(
J:127450
)
|
|
• smaller than wild-type controls
|
|
|
• testis weigh less than in wild-type mice (9.0+/-1.7 mg compared to 243.6+/-9.7 mg)
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