All Phenotypes Sirt1<tm1Ygu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sirt1^tm1Ygu
targeted mutation 1, Yansong Gu
MGI:3764971

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt1^tm1Ygu/Sirt1^tm1Ygu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764980
cn2	Ccar2^tm1Dac/Ccar2^tm1Dac Sirt1^tm1Ygu/Sirt1^tm1Ygu Tg(SERPINA1-cre)1Arge/0	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5804112

Allelic Composition	Sirt1^tm1Ygu/Sirt1^tm1Ygu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1^tm1Ygu mutation (2 available); any Sirt1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121948 )

Allelic Composition	Ccar2^tm1Dac/Ccar2^tm1Dac Sirt1^tm1Ygu/Sirt1^tm1Ygu Tg(SERPINA1-cre)1Arge/0
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccar2^tm1Dac mutation (0 available); any Ccar2 mutation (40 available)
Sirt1^tm1Ygu mutation (2 available); any Sirt1 mutation (81 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:228688 )

N	• normal body weight and fat content

decreased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet gain less weight than controls and show no increase in body fat

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228688 )

N	• normal glucose tolerance

decreased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet gain less weight than controls and show no increase in body fat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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