Phenotypes associated with this allele

• Allele Symbol: Tpt1^tm1.1Yen
• Allele Name: targeted mutation 1.1, Hsin-Fang Yang-Yen
• Allele ID: MGI:3764984
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpt1^tm1.1Yen/Tpt1^tm1.1Yen	involves: 129 * C57BL/6	MGI:3764990

Genotype
MGI:3764990

hm1

• Allelic Composition: Tpt1^tm1.1Yen/Tpt1^tm1.1Yen
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:127458 )

• embryos die around E9 with death always occurring before turning of the embryo

embryo

increased embryonic epiblast cell apoptosis ( J:127458 )

• in E6.5 embryos, epiblast cell numbers are further reduced by an almost 4 fold increase in apoptosis rate

decreased embryonic epiblast cell proliferation ( J:127458 )

• in E5.5 embryos, there is a reduced number of cells in the epiblast (28 vs. 20 in wild-type) that is a result of reduced cellular proliferation

abnormal endoderm development ( J:127458 )

• defects in endoderm patterning

abnormal mesoderm development ( J:127458 )

• defects in mesoderm patterning

decreased embryo size ( J:127458 )

• smaller embryo size is noted as early as E6.5 and is severely growth retarded by E9.5

abnormal primitive streak formation ( J:127458 )

• in E7.5 embryos, there is impaired progression of the primitive streak with a pattern of Brachyury staining similar to an E6.0 age embryo

failure of chorioallantoic fusion ( J:127458 )

• chorioallantoic fusion fails to occur prior to death at E9.5

growth/size/body

decreased embryo size ( J:127458 )

• smaller embryo size is noted as early as E6.5 and is severely growth retarded by E9.5

cellular

increased embryonic epiblast cell apoptosis ( J:127458 )

• in E6.5 embryos, epiblast cell numbers are further reduced by an almost 4 fold increase in apoptosis rate

decreased embryonic epiblast cell proliferation ( J:127458 )

• in E5.5 embryos, there is a reduced number of cells in the epiblast (28 vs. 20 in wild-type) that is a result of reduced cellular proliferation