Phenotypes associated with this allele

• Allele Symbol: Grid2^tm1Mmsh
• Allele Name: targeted mutation 1, Masayoshi Mishina
• Allele ID: MGI:3765001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2^tm1Mmsh/Grid2^tm1Mmsh	involves: C57BL/6N	MGI:3765152

Genotype
MGI:3765152

hm1

• Allelic Composition: Grid2^tm1Mmsh/Grid2^tm1Mmsh
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:127449 )

N • however, the cerebellum morphology and the fine structures of the parallel fibers-Purkinje cell synapses are normal

N • the area covered by climbing fibers is increased compared to in wild-type mice and ectopic climbing fibers innervate at distal dendrites

abnormal Purkinje cell morphology ( J:127449 )

• fewer Purkinje cells are innervated by a single climbing fiber (33% compared to 78% in wild-type mice) and the majority are innervated by one or two supernumerary climbing fibers in addition to the main climbing fiber

abnormal CNS synaptic transmission ( J:127449 )

• paired-pulse ratio is higher than in wild-type mice at shorter interpulse intervals

abnormal excitatory postsynaptic currents ( J:127449 )

• while some surplus climbing fibers display slower kinetics others display equivalent kinetics to the main climbing fiber EPSCs

prolonged excitatory postsynaptic current decay time ( J:127449 )

• in climbing fiber excitatory postsynaptic currents

• surplus climbing fiber EPSCs have rise times longer than 5 ms and decay times longer than 45 ms while all main climbing fiber EPSCs have rise times shorter than 5 ms and decay times shorter than 45 ms

prolonged excitatory postsynaptic current rise time ( J:127449 )

• in climbing fiber excitatory postsynaptic currents

• surplus climbing fiber EPSCs have rise times longer than 5 ms and decay times longer than 45 ms while all main climbing fiber EPSCs have rise times shorter than 5 ms and decay times shorter than 45 ms

reduced long-term depression ( J:127449 )

• long term depression is impaired at the parallel fibers-Purkinje cell synapses

behavior/neurological

behavior/neurological phenotype ( J:127449 )

N • mice do not display ataxia