Phenotypes associated with this allele

• Allele Symbol: Myt1^tm1.1Ggu
• Allele Name: targeted mutation 1.1, Guoqiang Gu
• Allele ID: MGI:3765056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myt1^tm1.1Ggu/Myt1^tm1.1Ggu	involves: 129 * C57BL/6 * CBA * CD-1 * SJL	MGI:3765058
cn2	Myt1^tm1Ggu/Myt1^tm1.1Ggu Tg(Pdx1-cre)89.1Dam/?	involves: 129 * C57BL/6 * CBA * CD-1 * SJL	MGI:3765063

Genotype
MGI:3765058

hm1

• Allelic Composition: Myt1^tm1.1Ggu/Myt1^tm1.1Ggu
• Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:127471 )

• mice die immediately after birth due to an inability to breath

endocrine/exocrine glands

abnormal PP cell physiology ( J:127471 )

• in 18.5 embryos, 20% of pancreatic polypeptide producing cells also express somatostatin which represents a 7 fold increase compared to wild-type controls

• in 18.5 embryos, 7.8%% of pancreatic polypeptide producing cells also express insulin which represents a 2 fold increase compared to wild-type controls

muscle

abnormal diaphragm morphology ( J:127471 )

• diaphragm is not innervated by birth leading to loss of function

Genotype
MGI:3765063

cn2

• Allelic Composition: Myt1^tm1Ggu/Myt1^tm1.1Ggu; Tg(Pdx1-cre)89.1Dam/?
• Genetic Background: involves: 129 * C57BL/6 * CBA * CD-1 * SJL

homeostasis/metabolism

decreased insulin secretion ( J:127471 )

• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls

impaired glucose tolerance ( J:127471 )

• 30 minutes after glucose injection, mice only had a 30% rise in insulin compared to a 100% rise in wild-type mice

endocrine/exocrine glands

abnormal pancreas development ( J:127471 )

• Mafb production in cells producing more than one hormone suggests delayed maturity of the secretory cells of the pancreas

abnormal PP cell physiology ( J:127471 )

• 10% of pancreatic polypeptide producing cells also express somatostatin which represents a 5 fold increase compared to wild-type controls

• 4.1% of pancreatic polypeptide producing cells also express insulin which represents a 20 fold increase compared to wild-type controls

abnormal pancreatic alpha cell physiology ( J:127471 )

• 2.7% of glucogon producing cells also produce insulin representing a 10 fold increase over wild-type controls

abnormal pancreas secretion ( J:127471 )

decreased insulin secretion ( J:127471 )

• islet cells isolated from 12 week old males secrete a third less insulin in response to high glucose as compared to wild-type controls

abnormal pancreatic somatostatin secretion ( J:127471 )