All Phenotypes Cd4<tm1Doi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^tm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:3765235

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cd4^tm1Doi/Cd4^tm1Doi Lag3^tm1Doi/Lag3^tm1Doi	involves: 129 * C57BL/6	MGI:3765244
cx2	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺	involves: 129 * C57BL/6	MGI:3765245

Allelic Composition	Cd4^tm1Doi/Cd4^tm1Doi Lag3^tm1Doi/Lag3^tm1Doi
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Doi mutation (0 available); any Cd4 mutation (85 available)
Lag3^tm1Doi mutation (2 available); any Lag3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

hematopoietic system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

Allelic Composition	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Doi mutation (0 available); any Cd4 mutation (85 available)
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (85 available)
Lag3^tm1Doi mutation (2 available); any Lag3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

hematopoietic system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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