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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
transgene insertion 21, Mathias Jucker
MGI:3765351
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0 		B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt MGI:4452492
cx2
 		Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 		C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:4452489
cx3
 		Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 		FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301408
cx4
 		Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 		FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301407
cx5
 		Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 		FVB.Cg-Abcg2tm1Ahs Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301409
cx6
 		Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5697919
cx7
 		Hdac6tm1Anfi/Hdac6tm1Anfi
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? 		involves: C57BL/6 MGI:5792144
cx8
 		Flot1tm1.1Arte/Flot1tm1.1Arte
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? 		involves: C57BL/6J MGI:5697918
cx9
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2em1Gela/Trem2+ 		involves: C57BL/6J MGI:6198554
cx10
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2tm1(KOMP)Vlcg/Trem2+ 		involves: C57BL/6J * C57BL/6NTac MGI:6198555
tg11
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0 C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5313530
tg12
 		Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? involves: C57BL/6 MGI:5792143


Genotype
MGI:4452492
cx1
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
Genetic
Background		 B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
Tg(Thy1-MAPT*P301S)2541Godt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
tau protein deposits ( J:159279 )
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Genotype
MGI:4452489
cx2
Allelic
Composition		 Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)7Jckr mutation (1 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:159279 )
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloidosis ( J:159279 )
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
amyloid beta deposits ( J:159279 )
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:5301408
cx3
Allelic
Composition		 Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:5301407
cx4
Allelic
Composition		 Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (76 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:178230 )
• increase in microgliosis
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

hematopoietic system
microgliosis ( J:178230 )
• increase in microgliosis

immune system
microgliosis ( J:178230 )
• increase in microgliosis

homeostasis/metabolism
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:178230




Genotype
MGI:5301409
cx5
Allelic
Composition		 Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 FVB.Cg-Abcg2tm1Ahs Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg2tm1Ahs mutation (2 available); any Abcg2 mutation (76 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:178230 )
• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice

homeostasis/metabolism
amyloid beta deposits ( J:178230 )
• mutants exhibit a similar amount of cortical amyloid beta-positive plaques as seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr transgenic mice




Genotype
MGI:5697919
cx6
Allelic
Composition		 Flot1tm1.1Arte/Flot1tm1.1Arte
Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
Flot2Gt(258D8)Cmhd mutation (0 available); any Flot2 mutation (38 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:212342 )
• reduced quantity of Abeta fragments

nervous system
amyloid beta deposits ( J:212342 )
• reduced quantity of Abeta fragments




Genotype
MGI:5792144
cx7
Allelic
Composition		 Hdac6tm1Anfi/Hdac6tm1Anfi
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1Anfi mutation (0 available); any Hdac6 mutation (17 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:234763 )
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes

nervous system
amyloid beta deposits ( J:234763 )
• mice show a similar amyloid beta plaque load as single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes

behavior/neurological
behavior/neurological phenotype ( J:234763 )
N
• mice show rescue of the mild hyperactivity seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes
• mice show complete rescue of the impaired freezing behavior seen in single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes, restoring associative memory
• mice show improved spatial memory function compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr hemizygotes




Genotype
MGI:5697918
cx8
Allelic
Composition		 Flot1tm1.1Arte/Flot1tm1.1Arte
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:212342 )
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques

nervous system
amyloid beta deposits ( J:212342 )
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques




Genotype
MGI:6198554
cx9
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2em1Gela/Trem2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
Trem2em1Gela mutation (0 available); any Trem2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased myeloid cell number ( J:264653 )
• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
abnormal hematopoietic system physiology ( J:264653 )
• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:264653 )
• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system
amyloid beta deposits ( J:264653 )
• mice show a 31% and 36% reduction in compact fibrillary, thioflavin S positive plaque number and percent area, respectively, in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating altered plaque structure
• however, the total number of cortical plaques and percent area is similar to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show a decrease in soluble amyloid beta 1-40 in the cortex and thus an increased ratio of amyloid beta 42/40 compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
abnormal neurite morphology ( J:264653 )
• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:6198555
cx10
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Trem2tm1(KOMP)Vlcg/Trem2+
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
Trem2tm1(KOMP)Vlcg mutation (1 available); any Trem2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased myeloid cell number ( J:264653 )
• mice show a reduction in the number of plaque-associated myeloid cells compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice, indicating an impairment in myeloid cell accumulation around plaques
abnormal hematopoietic system physiology ( J:264653 )
• proliferation of myeloid cells is reduced compared to levels in single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
amyloid beta deposits ( J:264653 )
• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

nervous system
amyloid beta deposits ( J:264653 )
• mice exhibit a modest increase in the total cortical plaque number and percent area compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
• mice show an increase in soluble amyloid beta 1-40 in the hippocampus compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
abnormal neurite morphology ( J:264653 )
• marker analysis indicates increased plaque-associated neuritic dystrophy compared to single transgenic Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:5313530
tg11
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:180835 )
• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates

homeostasis/metabolism
amyloid beta deposits ( J:180835 )
• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age
• newly formed plaques and preexisting plaques grow at similar rates

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:180835




Genotype
MGI:5792143
tg12
Allelic
Composition		 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal associative learning ( J:234763 )
• mice show impaired associative memory
abnormal spatial reference memory ( J:234763 )
• mice show impaired preference for the target quadrant in the probe test of the Morris Water Maze indicating impaired spatial memory function
hyperactivity ( J:234763 )
• mild hyperactivity

cellular
abnormal cell physiology ( J:234763 )
• mice show an increase in the immunoreactivity to Tom20, a marker for mitochondrial localization, in the soma, indicating accumulation of mitochondria at the somata of nerve cells and impaired mitochondrial trafficking

homeostasis/metabolism
amyloid beta deposits ( J:234763 )
• amyloid beta plaque

nervous system
amyloid beta deposits ( J:234763 )
• amyloid beta plaque

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:234763




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Send questions and comments to User Support. 		last database update
11/12/2024
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