Analysis Tools|
Allele Symbol Allele Name Allele ID |
Klf2tm1Mlkn targeted mutation 1, Mark L Kahn MGI:3765423 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation
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• tamoxifen injected mice exhibit a marked (80%) but incomplete prevention of cerebral cavernous malformation lesion formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit 99% rescue of cerebral cavernous malformation lesion formation, with only a small amount of venule dilatation visible
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos are all dead by E14.5
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• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
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• by E12.5, the myocardium has pulled away from the epicardium
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• by E12.5, large effusions are apparent around the embryonic heart
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• in E11.5 embryos, cardiac outputs are nearly 3 fold higher than in littermate controls
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• in E11.5 embryos, left ventricular stroke volume is 2.5 fold higher than in controls
• no evidence of valvular regurgitation is detected, indicating that excess flow is in the outward direction
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• maternal administration of a smooth muscle tone agonist rescues half of E14.5 embryos from lethality related to cardiac failure
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• at E12.5, 25% of embryos lack a heartbeat with the remaining embryos having a slower heartbeat (86 bpm vs 128 bpm)
• by E14.5 all embryos have lost their heartbeat
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• at E12.5, some yolk sacs are poorly perfused while others are devoid of blood
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• mice have normal amounts of erthyrocytes and do not display other signs of anemia
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• by E12.5, large effusions are apparent around the embryonic heart
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• by E12.5, the myocardium of is only 1-2 cell layers thick compared to a thickness of 5 cell layers or more in littermate controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice lack T cells in the peripheral blood
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• mice lack T cells in the peripheral blood
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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