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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Hmgcr-MX1)LStae
transgene insertion L, Peter Staeheli
MGI:3765440
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae 		involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3765897
cx2
 		Mx1s1/Mx1s1
Tg(Hmgcr-MX1)LStae/? 		involves: C57BL/6 * SJL MGI:3765443
tg3
 		Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:3765899


Genotype
MGI:3765897
cx1
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (60 available)
Tg(Hmgcr-MX1)LStae mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days
• only 43% of mice die from La Crosse virus infection as opposed to Ifnar1tm1Agt mice in which 94% die
• only 59% of mice die from Semliki Forest virus infection as opposed to 100% of Ifnar1tm1Agt mice

immune system
decreased susceptibility to Orthomyxoviridae infection ( J:119783 )
• no Thogoto virus is detectable in liver 36 hours after infection
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days
• only 43% of mice die from La Crosse virus infection as opposed to Ifnar1tm1Agt mice in which 94% die
• only 59% of mice die from Semliki Forest virus infection as opposed to 100% of Ifnar1tm1Agt mice




Genotype
MGI:3765443
cx2
Allelic
Composition		 Mx1s1/Mx1s1
Tg(Hmgcr-MX1)LStae/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1s1 mutation (26 available); any Mx1 mutation (81 available)
Tg(Hmgcr-MX1)LStae mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )
• decreased lethality is observed in mice challenged with influenza A virus or VSV
• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )
• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died
• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)
• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls

immune system
decreased susceptibility to Riboviria infection ( J:128067 )
• supernatant of embryonic fibroblasts infected with VSV contains 10-40 fold less infectious particles 25 hours after infection
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:128067 )
• decreased lethality is observed in mice challenged with influenza A virus or VSV
• mice infected with VSV by an intracerebal route have longer mean survival times (2.7 days vs. 1.5)
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:128067 )
• no lethality is observed in mice challenged with Thogoto virus while all the littermate controls died
• mice infected with influenza A virus by an intracerebal route have longer mean survival times (6.0 days vs. 3.9)
• mice infected with pneumotropic influenza A virus have increased rates of survival (33.3% vs 0%) for wild-type controls
decreased susceptibility to Orthomyxoviridae infection ( J:128067 )
• supernatant of embryonic fibroblasts infected with influenza A virus contains 10-40 fold less infectious particles 25 hours after infection
• supernatant of embryonic fibroblasts infected with Thogoto virus contains no infectious particles 3 days after infection




Genotype
MGI:3765899
tg3
Allelic
Composition		 Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days

immune system
decreased susceptibility to Orthomyxoviridae infection ( J:119783 )
• no Thogoto virus is detectable in liver 36 hours after infection
decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:119783 )
• mice infected with Thogoto virus all survive while littermate controls die within 5 days




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory