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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncor2tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:3765904
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ncor2tm1Rsd/Ncor2tm1Rsd involves: 129S1/Sv * 129X1/SvJ MGI:3765908
cx2
 		Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+ 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:3765909
cx3
 		Foxp1Gt(S17-4A1)Sor/Foxp1+
Ncor2tm1Rsd/Ncor2+ 		involves: 129/Sv * 129S4/SvJaeSor MGI:3783622
cx4
 		Ncor2tm1Rsd/Ncor2tm1Rsd
Tg(Myh6-Ncor2)1Kjep/? 		involves: 129/Sv * BALB/c * C57BL/6 MGI:3765964


Genotype
MGI:3765908
hm1
Allelic
Composition		 Ncor2tm1Rsd/Ncor2tm1Rsd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:127720 )
• mice die before E16.5 due to heart defects

cardiovascular system
abnormal heart development ( J:127720 )
• mice die before E16.5 due to heart defects
ventricular septal defect ( J:132982 )
• at E11.5 and E14.5
thin ventricular wall ( J:132982 )
• at E11.5 and E14.5

nervous system
abnormal neuronal precursor proliferation ( J:127720 )
• after 4 to 6 days in culture, cortical progenitor cells exhibit decreased proliferation with signs of differentiation unlike to wild-type cells
• E13 cortical progenitor cells are multipotent
abnormal telencephalon morphology ( J:127720 )
• at E14.5, the hippocampus, neocortex and palaeocortex are slightly smaller than in wild-type mice

cellular
abnormal neuronal precursor proliferation ( J:127720 )
• after 4 to 6 days in culture, cortical progenitor cells exhibit decreased proliferation with signs of differentiation unlike to wild-type cells
• E13 cortical progenitor cells are multipotent




Genotype
MGI:3765909
cx2
Allelic
Composition		 Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1Rsd mutation (1 available); any Ncor1 mutation (396 available)
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:127720 )
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells

cellular
abnormal neuron differentiation ( J:127720 )
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells




Genotype
MGI:3783622
cx3
Allelic
Composition		 Foxp1Gt(S17-4A1)Sor/Foxp1+
Ncor2tm1Rsd/Ncor2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1Gt(S17-4A1)Sor mutation (0 available); any Foxp1 mutation (77 available)
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:132982 )
• fewer than expected mice are recovered at birth

cardiovascular system
thin myocardium ( J:132982 )
• in 50% of mice at E14.5
ventricular septal defect ( J:132982 )
• in 50% of mice at E14.5

muscle
thin myocardium ( J:132982 )
• in 50% of mice at E14.5




Genotype
MGI:3765964
cx4
Allelic
Composition		 Ncor2tm1Rsd/Ncor2tm1Rsd
Tg(Myh6-Ncor2)1Kjep/?
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (170 available)
Tg(Myh6-Ncor2)1Kjep mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:127720 )
N
• mice survive until birth with no heart defects

nervous system
abnormal telencephalon development ( J:127720 )
• at E17.5, mice exhibit a shift in the proportional volume of the dorsal and ventral telencephalon
thin cortical plate ( J:127720 )
• the neocortical plate is thinned in the medial and lateral regions extending throughout the rostro-caudal axis of the brain and includes the hippocampus
abnormal cerebral cortex morphology ( J:127720 )
• the ventral-lateral boundaries of the neocortex and palaeocortex terminate in more dorsa positions
• axonal projections linking opposing cortical hemispheres are altered compared to in wild-type mice
• axons between the thalamus and cortex are more highly represented than in wild-type mice

craniofacial
palatal shelves fail to meet at midline ( J:127720 )
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)
cleft secondary palate ( J:127720 )
• at E17.5 mice exhibit secondary cleft palate

digestive/alimentary system
palatal shelves fail to meet at midline ( J:127720 )
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)
cleft secondary palate ( J:127720 )
• at E17.5 mice exhibit secondary cleft palate

growth/size/body
palatal shelves fail to meet at midline ( J:127720 )
• at E17.5, palatal shelves do not meet at the midline (Sup. Fig. 1e)
cleft secondary palate ( J:127720 )
• at E17.5 mice exhibit secondary cleft palate




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory