Phenotypes associated with this allele

• Allele Symbol: Actr3^{Gt(A009F03)Vau}
• Allele Name: gene trap mutation A009F03, Franz Vauti
• Allele ID: MGI:3765916
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actr3^Gt(A009F03)Vau/Actr3^Gt(A009F03)Vau	involves: 129P2/OlaHsd * CD-1	MGI:3765918
ht2	Actr3^Gt(A009F03)Vau/Actr3^+	involves: 129P2/OlaHsd * CD-1	MGI:3765919

Genotype
MGI:3765918

hm1

• Allelic Composition: Actr3^{Gt(A009F03)Vau}/Actr3^{Gt(A009F03)Vau}
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:127731 )

• no mice are present by E4.5 and only 50% of expected embryos are present at E3.5

embryo

abnormal preimplantation embryo development ( J:127731 )

embryonic growth arrest ( J:127731 )

• at E3.5, 36 of 85 embryos exhibit developmental arrest and all embryos fail to develop in culture compared to only 30% of wild-type embryos

abnormal blastocyst morphology ( J:127731 )

• in culture blastocysts fail to attach to a gelatinized substrate and do not form outgrowths of trophoblast-like cells unlike wild-type cells

Genotype
MGI:3765919

ht2

• Allelic Composition: Actr3^{Gt(A009F03)Vau}/Actr3⁺
• Genetic Background: involves: 129P2/OlaHsd * CD-1

embryo

abnormal blastocyst morphology ( J:127731 )

• after 24 hours in culture, 25% of blastocysts collapse and show aberrant morphology