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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sarm1tm1Aidi
targeted mutation 1, Aihao Ding
MGI:3765956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sarm1tm1Aidi/Sarm1tm1Aidi involves: 129X1/SvJ * C57BL/6J MGI:3765957
cx2
 		Sarm1tm1Aidi/Sarm1tm1Aidi
Stmn2em1Jmi/Stmn2em1Jmi 		involves: 129X1/SvJ * C57BL/6J * C57BL/6N MGI:7523312


Genotype
MGI:3765957
hm1
Allelic
Composition		 Sarm1tm1Aidi/Sarm1tm1Aidi
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sarm1tm1Aidi mutation (1 available); any Sarm1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased apoptosis ( J:126083 )
• in response to oxygen and glucose deprivation, hippocampus cells exhibit reduced apoptosis (31.89+/-3.34% compared to 67.21+/-5.10% in wild-type cells)

immune system
immune system phenotype ( J:126083 )
N
• macrophages exhibit normal function




Genotype
MGI:7523312
cx2
Allelic
Composition		 Sarm1tm1Aidi/Sarm1tm1Aidi
Stmn2em1Jmi/Stmn2em1Jmi
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sarm1tm1Aidi mutation (1 available); any Sarm1 mutation (25 available)
Stmn2em1Jmi mutation (0 available); any Stmn2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased grip strength ( J:337175 )
• at 3 months of age, mice show a decrease in the latency time (s) to fall from an inverted screen that is similar to that in single Stmn2em1Jmi homozygotes, indicating severe motor function impairment

nervous system
abnormal neuromuscular synapse morphology ( J:337175 )
• lumbrical muscle NMJs exhibit presynaptic and postsynaptic elements that are indistinguishable from those of single Stmn2em1Jmi homozygotes, including endplate fragmentation and many regions of partial innervation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory