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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gprc5atm1Rlo
targeted mutation 1, Reuben Lotan
MGI:3765976
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gprc5atm1Rlo/Gprc5atm1Rlo involves: 129 * C57BL/6 MGI:3765978
ht2
 		Gprc5atm1Rlo/Gprc5a+ involves: 129 * C57BL/6 MGI:3765979


Genotype
MGI:3765978
hm1
Allelic
Composition		 Gprc5atm1Rlo/Gprc5atm1Rlo
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprc5atm1Rlo mutation (0 available); any Gprc5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:127821 )
• visual inspection during necropsy indicates mice have a 63.6% incidence of lung tumors compared to 2% in wild-type controls
increased lung adenoma incidence ( J:127821 )
• histopathology indicates increased incidence of adenomas (76% vs. 10% in littermate controls) in mice 1 to 2 years of age
increased lung adenocarcinoma incidence ( J:127821 )
• histopathology indicates increased incidence of adenocarcinomas (17% vs. 0% in littermate controls) in mice 1 to 2 years of age

respiratory system
lung inflammation ( J:127821 )
• the incidence of acidophilic macrophage pneumonia is 36.6% compared to 9.8% for littermate controls
increased lung tumor incidence ( J:127821 )
• visual inspection during necropsy indicates mice have a 63.6% incidence of lung tumors compared to 2% in wild-type controls
increased lung adenoma incidence ( J:127821 )
• histopathology indicates increased incidence of adenomas (76% vs. 10% in littermate controls) in mice 1 to 2 years of age
increased lung adenocarcinoma incidence ( J:127821 )
• histopathology indicates increased incidence of adenocarcinomas (17% vs. 0% in littermate controls) in mice 1 to 2 years of age

immune system
lung inflammation ( J:127821 )
• the incidence of acidophilic macrophage pneumonia is 36.6% compared to 9.8% for littermate controls




Genotype
MGI:3765979
ht2
Allelic
Composition		 Gprc5atm1Rlo/Gprc5a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprc5atm1Rlo mutation (0 available); any Gprc5a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:127821 )
• visual inspection during necropsy indicates mice have a 15.1% incidence of lung tumors compared to 2% in wild-type controls

respiratory system
increased lung tumor incidence ( J:127821 )
• visual inspection during necropsy indicates mice have a 15.1% incidence of lung tumors compared to 2% in wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory