All Phenotypes Akap5<tm1Gsm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akap5^tm1Gsm
targeted mutation 1, G Stanley Mcknight
MGI:3765995

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap5^tm1Gsm/Akap5^tm1Gsm	B6.129-Akap5^tm1Gsm	MGI:3765996
hm2	Akap5^tm1Gsm/Akap5^tm1Gsm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5448700

Allelic Composition	Akap5^tm1Gsm/Akap5^tm1Gsm
Genetic Background	B6.129-Akap5^tm1Gsm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap5^tm1Gsm mutation (1 available); any Akap5 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:127739 )

• hippocampal long term potentiation (LTP) induced by a single tetanus of 1s/100Hz is absent in 7-8 week old mice but is present in mice 4-5 weeks of age

• basal synaptic transmission is normal in 7-8 week old mice, suggesting loss of LTP is due to a post-synaptic mechanism

Allelic Composition	Akap5^tm1Gsm/Akap5^tm1Gsm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap5^tm1Gsm mutation (1 available); any Akap5 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:190017 )

N	• mice exhibit normal glucose handling

decreased circulating insulin level ( J:190017 )

• minimally following glucose challenge

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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