Phenotypes associated with this allele

• Allele Symbol: Tg(PLA2G2A)703Dsg
• Allele Name: transgene insertion 703, David S Grass
• Allele ID: MGI:3766007
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(PLA2G2A)703Dsg/?	involves: C57BL/6 * C57BL/6J * SJL	MGI:3766008

Genotype
MGI:3766008

tg1

• Allelic Composition: Tg(PLA2G2A)703Dsg/?
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:113573 )

• by day 16 mice are 25% smaller by weight compared to wild-type mice

behavior/neurological

decreased locomotor activity ( J:113573 )

• mice are ill-appearing and inactive

immune system

immune system phenotype ( J:113573 )

N • no abnormal immune infiltrate is observed in the skin, bone of the forepaw and hind foot, liver, lung, spleen, pancreas, brain and thymus

endocrine/exocrine glands

enlarged sebaceous gland ( J:113573 )

• adnexal hyperplasia is associated with an increase in the size of hair follicles with some follicular keratosis or dilation and hyperplasia of the surrounding sebaceaous glands

integument

enlarged sebaceous gland ( J:113573 )

• adnexal hyperplasia is associated with an increase in the size of hair follicles with some follicular keratosis or dilation and hyperplasia of the surrounding sebaceaous glands

alopecia ( J:113573 )

• by day 16 mice develop severe alopecia

• while fur growth is reinitiated after day 21, mice fail to recover all their fur

• the severity of alopecia is associated with the level of transgene expression

enlarged hair follicles ( J:113573 )

• adnexal hyperplasia is associated with an increase in the size of hair follicles with some follicular keratosis or dilation and hyperplasia of the surrounding sebaceaous glands

hyperkeratosis ( J:113573 )

epidermal hyperplasia ( J:113573 )

thick skin ( J:113573 )

• by day 16 mice exhibit increased skin thickness (8 to 10 cells thick compared to 1 to 2 cells thick in wild-type mice) due to hyperkeratosis, epidermal hyperplasia and adnexal hyperplasia