mortality/aging
• diabetes-like symptoms (dehydration, weight loss) lead to death of most animals by 6 months of age
|
growth/size/body
weight loss
(
J:93555
)
immune system
• mice have a greater number of cytokine-positive cells (Il4 or Ifng) compared to mice coexpressing CD80 and the MHC class II transgene
|
• mice develop clinical signs of diabetes
|
endocrine/exocrine glands
• mice show autoimmune destruction of pancreatic beta cells
|
homeostasis/metabolism
• mice show elevated blood glucose levels (363 mg/dl at 8 weeks rising to 402 mg/dl at 6 months)
|
dehydration
(
J:93555
)