About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mnx1-cre)1Jrs
transgene insertion 1, Joshua R Sanes
MGI:3766074
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3766403
cn2
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/? 		involves: 129X1/SvJ * C57BL/6 MGI:3766402


Genotype
MGI:3766403
cn1
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Lamb2tm1Jrs/Lamb2tm1Jrs
Tg(Mnx1-cre)1Jrs/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Lamb2tm1Jrs mutation (1 available); any Lamb2 mutation (76 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic vesicle clustering ( J:126496 )
• at P14, vesicles were highly clustered at synaptic site, but were abundant in preterminal portions




Genotype
MGI:3766402
cn2
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(Mnx1-cre)1Jrs/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Tg(Mnx1-cre)1Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:126496 )
• smaller than litter mate controls
• born in expected Mendelian numbers

behavior/neurological
tremors ( J:126496 )
• exhibited a mild tremor

nervous system
abnormal synaptic vesicle clustering ( J:126496 )
• at embryonic stages, vesicles were less concentrated at synaptic sites than in controls
• a similar defect was observed in neonates and during the first postnatal week
• the abnormality was transient and barely detectable by the third postnatal week
• neuromuscular junctions formed on schedule




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory