Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(COL1A1)73Prc transgene insertion 73, Darwin J Prockop MGI:3766089 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• results suggest the incidence of neonatal lethality is increased in putative homozygous mice
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• mice die shortly after birth with extensive bone fractures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• one mouse died shortly after birth
(J:31417)
• about 6% of mice die shortly after birth with extensive bone fractures
(J:146429)
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• on a powdered diet teeth grow abnormally thin and long
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• mice on a pelleted diet develop broken teeth
• on a powdered diet fewer broken teeth are seen
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• extensive fractures of the long bones were seen in the mouse that died shortly after birth
(J:31417)
• long bone fractures are seen in about 33% of mice
(J:146429)
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• in the mouse that died shortly after birth
(J:31417)
• seen in about 33% of mice
(J:146429)
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• decreased mineral content in the long bones
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• decreased collagen content in the long bones
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• reduced mineralization of the skull in the mouse that died shortly after birth
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• about 6% of mice die shortly after birth with extensive bone fractures
• about 33% of mice have detectable bone fractures on the day of birth
• in femurs the force to failure and energy to failure are decreased
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• on a powdered diet teeth grow abnormally thin and long
|
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• mice on a pelleted diet develop broken teeth
• on a powdered diet fewer broken teeth are seen
|
|
• on a powdered diet teeth grow abnormally thin and long
|
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• mice on a pelleted diet develop broken teeth
• on a powdered diet fewer broken teeth are seen
|
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• limbs were limp in the mouse that died shortly after birth
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| osteogenesis imperfecta type 1 | DOID:0110334 |
OMIM:166200 |
J:146429 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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