Phenotypes associated with this allele

• Allele Symbol: Tg(Gfap-TNF*)K21Gkl
• Allele Name: transgene insertion K21, George Kollias
• Allele ID: MGI:3766134
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Gfap-TNF*)K21Gkl/0 Tnfrsf1a^tm1Blt/Tnfrsf1a^+	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4461138
tg2	Tg(Gfap-TNF*)K21Gkl/0	involves: C57BL/6 * CBA	MGI:4461137

Genotype
MGI:4461138

cx1

• Allelic Composition: Tg(Gfap-TNF*)K21Gkl/0; Tnfrsf1a^tm1Blt/Tnfrsf1a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:106592 )

• neurological symptoms by the sixth month of age, delayed compared to Tg alone

demyelination ( J:106592 )

• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592

Genotype
MGI:4461137

tg2

• Allelic Composition: Tg(Gfap-TNF*)K21Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

immune system

CNS inflammation ( J:106592 )

• a progressive accumulation of inflammatory cells at one week of age

nervous system

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 2 weeks of age

CNS inflammation ( J:106592 )

• a progressive accumulation of inflammatory cells at one week of age

abnormal astrocyte morphology ( J:106592 )

• at 4 weeks of age myelin loss is accompanied by astrocyte loss

astrocytosis ( J:106592 )

• widespread astrocytic gliosis starting at one week of age

abnormal meninges morphology ( J:106592 )

• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age

axon degeneration ( J:106592 )

• at 4 weeks of age myelin loss is accompanied by axonal damage

demyelination ( J:106592 )

• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592