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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Map2k1*)1Jmol
transgene insertion 1, Jeffery D Molkentin
MGI:3766499
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh7-cre)1Jmk/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:5141278
cx2
 		Gata4tm1.1Jmol/Gata4tm1.1Jmol
Tg(Myh6-Map2k1*)1Jmol/0 		involves: 129 * C57BL/6 * FVB MGI:5141280
cx3
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:5141279
cx4
 		Mapk1tm1Melo/Mapk1+
Tg(Myh6-Map2k1*)1Jmol/0 		involves: 129S2/SvPas * FVB MGI:3851931
cx5
 		Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Myh6-Map2k1*)1Jmol/0 		involves: 129/Sv * FVB/N MGI:3851930
cx6
 		Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0 		involves: FVB MGI:5897405
tg7
 		Tg(Myh6-Map2k1*)1Jmol/? involves: FVB MGI:3766501
tg8
 		Tg(Myh6-Map2k1*)1Jmol/? involves: FVB/N MGI:3766576


Genotype
MGI:5141278
cn1
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh7-cre)1Jmk/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
Tg(Myh7-cre)1Jmk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart size ( J:174537 )
• hypertrophy is markedly attenuated compared to mutant mice not expressing cre




Genotype
MGI:5141280
cx2
Allelic
Composition		 Gata4tm1.1Jmol/Gata4tm1.1Jmol
Tg(Myh6-Map2k1*)1Jmol/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Jmol mutation (1 available); any Gata4 mutation (36 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart size ( J:174537 )
• hypertrophy is markedly attenuated compared to transgenic mice wild-type for Gata4




Genotype
MGI:5141279
cx3
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:174537 )
• about a 30% increase in ventricular weight compared to mutant mice not carrying the transgene

growth/size/body
cardiac hypertrophy ( J:174537 )
• about a 30% increase in ventricular weight compared to mutant mice not carrying the transgene




Genotype
MGI:3851931
cx4
Allelic
Composition		 Mapk1tm1Melo/Mapk1+
Tg(Myh6-Map2k1*)1Jmol/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1Melo mutation (0 available); any Mapk1 mutation (43 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:124903 )
• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

growth/size/body
cardiac hypertrophy ( J:124903 )
• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals




Genotype
MGI:3851930
cx5
Allelic
Composition		 Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Myh6-Map2k1*)1Jmol/0
Genetic
Background		 involves: 129/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:124903 )
• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

growth/size/body
cardiac hypertrophy ( J:124903 )
• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals




Genotype
MGI:5897405
cx6
Allelic
Composition		 Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
thick interventricular septum ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol and wild-type mice
increased heart weight ( J:234490 )
• compared with wild-type mice
abnormal heart left ventricle morphology ( J:234490 )
• left ventricular wall thickness is increased compared with wild-type and Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
• however, left ventricle size is rescued compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased cardiac muscle contractility ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle
increased cardiac muscle contractility ( J:234490 )
• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body
increased heart weight ( J:234490 )
• compared with wild-type mice




Genotype
MGI:3766501
tg7
Allelic
Composition		 Tg(Myh6-Map2k1*)1Jmol/?
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber size ( J:66102 )
• about 30% increase in the cross-sectional area of each myocardial fiber
heart left ventricle hypertrophy ( J:66102 )
• there is about a 50% increase left ventricular posterior wall thickness
increased heart weight ( J:66102 )
• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age
thick ventricular wall ( J:66102 )
• there is about a 50% increase in septal thickness and left ventricular posterior wall thickness
decreased left ventricle diastolic pressure ( J:66102 )
• diastolic function is reduced due to decreased ventricular volume
increased left ventricle systolic pressure ( J:66102 )
• greater than 10% increase in left ventricular systolic pressure

muscle
increased myocardial fiber size ( J:66102 )
• about 30% increase in the cross-sectional area of each myocardial fiber
heart left ventricle hypertrophy ( J:66102 )
• there is about a 50% increase left ventricular posterior wall thickness
decreased cardiomyocyte apoptosis ( J:66102 )
• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery

cellular
decreased cardiomyocyte apoptosis ( J:66102 )
• less apoptosis is observed in mice subjected to ischemia/reperfusion of the left coronary artery

growth/size/body
heart left ventricle hypertrophy ( J:66102 )
• there is about a 50% increase left ventricular posterior wall thickness
increased heart weight ( J:66102 )
• increased heart:body weight ratio of 34, 41, and 23% is observed at 3 weeks, 8 weeks, and 6 months of age




Genotype
MGI:3766576
tg8
Allelic
Composition		 Tg(Myh6-Map2k1*)1Jmol/?
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac output ( J:127872 )
• 7 days after ischemia injury, mice have no loss of cardiac output compared to 50% loss in wild-type controls
decreased myocardial infarct size ( J:127872 )
• there is two-third less infarction of the left ventricular area after ischemia/reperfusion injury

muscle
decreased cardiomyocyte apoptosis ( J:127872 )
• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury

homeostasis/metabolism
decreased myocardial infarct size ( J:127872 )
• there is two-third less infarction of the left ventricular area after ischemia/reperfusion injury

cellular
decreased cardiomyocyte apoptosis ( J:127872 )
• eight fold less cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory