mortality/aging
• no homozygotes are seen at E18.5
|
Allele Symbol Allele Name Allele ID |
Del(11Mpo-Chad)18Brd deletion, Chr 11, Allan Bradley 18 MGI:3766573 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygotes are seen at E18.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• majority of heterozygotes are born alive, however about 15% die within several hours of birth
|
• 5 of 38 mutants display a hypoplastic pulmonary trunk
|
• 32% of E18.5 fetuses exhibit structural heart defects
• 5 of 38 mutants exhibit two or more abnormalities that are characteristic of the tetralogy of Fallot complex, including perimembranous ventricular septal defects, overriding of the aorta, and hypoplastic pulmonary trunks
• howerver, mutants do not develop patent ductus arteriosus and dilated left atrium and ventricle
|
• seen in 5 of 38 mutants at E18.5
|
• 8 of 38 fetuses exhibit transposition of the great arteries
|
• 7 of 38 mutants have perimembranous ventricular septal defects
|
• 8 of 38 mutants have inlet ventricular septal defects
|
• 4 of 38 mutants exhibit deviation of the parietal muscle band which causes subpulmonary stenosis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dextro-looped transposition of the great arteries | DOID:0060770 |
OMIM:608808 |
J:109163 | |
tetralogy of Fallot | DOID:6419 |
OMIM:187500 |
J:109163 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|