Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Thy1-EGFP)MJrs transgene insertion M, Joshua R Sanes MGI:3766828 |
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| Summary |
18 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• deformed hippocampus
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• mice die before age P17
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer entries into and time spent in open arms in elevated plus maze test
• normal total distance travelled and time spent in closed arms in elevated plus maze test
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• less time spent in center in open field test
• normal distance traveled in open field test
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• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test
• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test
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| N |
• normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight
• normal neuron morphology in CA1 and hippocampal regions and in cerebral neocortex layers
• normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons
• normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons
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• increased number of spines on apical dendrites of hippocampal CA1 neurons
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• increased mEPSC frequency in hippocampal CA1 pyramidal neurons
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• increased mIPSC frequency in hippocampal CA1 pyramidal neurons
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| N |
• viable and normal lifespan
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| N |
• normal body size
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| N |
• fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in brain size due to expansion of allocortex and neocortex
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• apical dendrites of pyramidal neurons in cortical layer 2/3 but not layer 5 are longer and more tortuous than in controls
• total arbor length is on average 1.6 mm longer in mutants, indicating an approximate 80% expansion of the apical dendritic tree
• however, basal dendritic length is not different
• rapamycin treatments completely prevent dendritic growth seen following Pten deletion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction in the number and volume of mushroom, thin, and filopodium spines
• however, stubby spine numbers are normal
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• with reduced complexity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors
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• impaired in tamoxifen-treated mice
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• impaired in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze
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• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
• however, general neuron morphology is normal
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• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
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• reduced in tamoxifen-treated mice
• however, excitability is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 85% of labeled retinal ganglion cells have dendrites that arborize broadly within the inner plexiform layer, extending into the inner nuclear layer, outer plexiform layer, and, in a few cases, the outer nuclear layer
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• about 85% of labeled retinal ganglion cells have dendrites that arborize broadly within the inner plexiform layer, extending into the inner nuclear layer, outer plexiform layer, and, in a few cases, the outer nuclear layer
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• about 85% of labeled retinal ganglion cells have dendrites that arborize broadly within the inner plexiform layer, extending into the inner nuclear layer, outer plexiform layer, and, in a few cases, the outer nuclear layer
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• labeled retinal ganglion cells show mild dendritic arborization defects
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• labeled retinal ganglion cells show mild dendritic arborization defects
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• labeled retinal ganglion cells show mild dendritic arborization defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant reduction in glutaminergic synapse density, as measured by number of spines on secondary dendrites of hippocampal CA1 neurons at age P21-23
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice
• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dendritic arborizations are much simpler in layer II/III of the cerebral cortex at P90
• total dendritic length is decreased by 27.8% and secondary and tertiary branching levels are significantly reduced
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• spine density is reduced by 15.6% on apical dendrites
• spine density in layer V/VI of the cortex is reduced at P42 and P90
• spine density in layer V/VI of the cortex remains relatively constant from P21 to P42 to P90 unlike in wild-type controls where spine density increases across these ages
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slight but significant decrease in the fraction of stubby spines but mean spine density remains unchanged
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• significant decrease in the mean total number of branching points and mean total path length of apical dendrites but not for basal dendrites
• significantly diminished mean number of apical dendritic intersections at 150 and 240 m distance from the soma
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• mean area covered by postsynaptic density is increased by 70% compared to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the necks of dendritic spines exhibit decreased neck diameter compared to in wild-type mice
• the proportion of mushroom spines in increased while the number of stubby spines is decreased compared to in wild-type mice
• spine length on mushroom spines is increased compared to in wild-type mice
• however, the total number of spines is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4-fold increase in axon branching in the callosum
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• 4-fold increase in axon branching in the callosum
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• increased thickness
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• 4-fold increase in axon branching in the callosum
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction in number of dendritic spines on neurons from the entorhinal cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• marker analysis indicates an asymmetric enrichment of NMDA and AMPA receptors in the left and right postsynaptic density of hippocampi
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• mice show decreased spine volumes in secondary basal dendrites of left hippocampal CA1 pyramidal neurons, but not in right hemisphere CA1 pyramidal neurons; mushroom, stubby, and filopodia spines all show a decrease in spine volume
• volumes of mushroom, stubby, and filopdia spines are also decreased in apical dendrites of the left hippocampus, while only filopodia spine volumes are reduced in the right hippocampus
• hippocampal neurons from E18 mutants grown in culture show a decreased ratio of stubby spine but an increased ratio of filopodia spine in the secondary dendrites and decreased spine density and volume
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• mice show an increased ratio of stubby spines but a decreased ratio of long thin spines in the bilateral hippocampus, indicating an increase in the density of mature spines
• however, no difference in spine density is seen in apical dendrites
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• CA1 pyramidal neurons show reduced secondary dendritic spine volume in the left hippocampus but not right hippocampus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:270945 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• type III CA1 pyramidal neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CA1 pyramidal neurons bifurcate at the stratum pyramidale layer
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• in CA1 pyramidal neurons
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• of type III CA1 pyramidal neurons
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• cultured hippocampal neurons exhibit increased number of branching points compared with wild-type neurons
• neither number of branching points or total length is changed by Sema3A treatment unlike in wild-type cells
• however, dendrite length is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased number of neurites in CA1 and CA2 layers of dorsal hippocampus
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• increased number of primary dendrites with dendritic spines in CA1 and CA2 layers of dorsal hippocampus
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| N |
• normal mitochondrial morphology in in proximal and distal regions of hippocampal dendrites
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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