Phenotypes associated with this allele

• Allele Symbol: Adamts20^bt-2H
• Allele Name: belted 2 Harwell
• Allele ID: MGI:3766915
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts20^bt-2H/Adamts20^bt-2H	B6.Cg-Adamts20^bt-2H	MGI:3783649
hm2	Adamts20^bt-2H/Adamts20^bt-2H	JU.Cg-Adamts20^bt-2H	MGI:3783648
cx3	Adamts20^bt-2H/Adamts20^bt-2H Adamts9^tm1Dgen/Adamts9^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4418869
cx4	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit^tm1Alf	involves: 129S2/SvPas * C57BL/6	MGI:3783651
cx5	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit^+	involves: 129S2/SvPas * C57BL/6	MGI:3783653
cx6	Adamts20^bt-2H/Adamts20^bt-2H Tg(Dct-lacZ)A12Jkn/0	involves: C57BL/6 * CBA	MGI:3783650

Genotype
MGI:3783649

hm1

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H
• Genetic Background: B6.Cg-Adamts20^bt-2H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

belted ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

white spotting ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

integument

belted ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

white spotting ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

Genotype
MGI:3783648

hm2

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H
• Genetic Background: JU.Cg-Adamts20^bt-2H

pigmentation

belted ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

white spotting ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

integument

belted ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

white spotting ( J:106083 )

• mice exhibit white spots on the posterior that can resemble a belt regardless of whether the mouse is on a C57BL/6 or JU background

Genotype
MGI:4418869

cx3

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Adamts9^tm1Dgen/Adamts9⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:133403 )

• die shortly after birth

pigmentation

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

embryo

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

nervous system

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

integument

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

Genotype
MGI:3783651

cx4

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Kit^tm1Alf/Kit^tm1Alf
• Genetic Background: involves: 129S2/SvPas * C57BL/6

pigmentation

belted ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

white spotting ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

integument

belted ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

white spotting ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

Genotype
MGI:3783653

cx5

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

pigmentation

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

integument

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

Genotype
MGI:3783650

cx6

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Tg(Dct-lacZ)A12Jkn/0
• Genetic Background: involves: C57BL/6 * CBA

pigmentation

pigmentation phenotype ( J:133403 )

N • despite white spotting, melanoblast initial specification and migration are normal

belted ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

white spotting ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

embryo

abnormal melanoblast migration ( J:133403 )

• as early as E13.5, melanoblasts fail to distribute uniformly across dorsal and lateral surfaces of the trunk unlike in wild-type mice

• however, head distribution of melanoblasts is normal and the relative distribution through out the skin layers is normal

• melanoblasts are lacking in areas corresponding to the future belt as early as E15.5 and E16.5

• while melanoblast proliferation is normal, melanoblast survival is reduced compared to in wild-type mice

• unlike in wild-type mice, there is no difference in the melanoblast number between the head and trunk

• apoptosis of melanoblasts is increased 7-fold in the head and to a lesser extent in the trunk compared to in wild-type mice

• fewer melanoblasts survive and migrate into the hair follicle than in wild-type mice

integument

belted ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

white spotting ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

cellular

abnormal melanoblast migration ( J:133403 )

• as early as E13.5, melanoblasts fail to distribute uniformly across dorsal and lateral surfaces of the trunk unlike in wild-type mice

• however, head distribution of melanoblasts is normal and the relative distribution through out the skin layers is normal

• melanoblasts are lacking in areas corresponding to the future belt as early as E15.5 and E16.5

• while melanoblast proliferation is normal, melanoblast survival is reduced compared to in wild-type mice

• unlike in wild-type mice, there is no difference in the melanoblast number between the head and trunk

• apoptosis of melanoblasts is increased 7-fold in the head and to a lesser extent in the trunk compared to in wild-type mice

• fewer melanoblasts survive and migrate into the hair follicle than in wild-type mice