About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrna4tm2Dra
targeted mutation 2, John Drago
MGI:3767041
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Chrna4tm2Dra/Chrna4+ involves: 129S1/Sv * CD-1 MGI:3767043


Genotype
MGI:3767043
ht1
Allelic
Composition		 Chrna4tm2Dra/Chrna4+
Genetic
Background		 involves: 129S1/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm2Dra mutation (0 available); any Chrna4 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavioral response to addictive substance ( J:125305 )
• most mice (28 of 29) display saccadic behavior of Straub tailing following injection of 2 mg/kg nicotine
• only rarely (1 of 29) do mice display forelimb dystonia after nicotine injection (2 mg/kg) unlike mice heterozygous for Chrna4tm2.1Dra




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory