Phenotypes associated with this allele

• Allele Symbol: Epo^{Tg(TAg/Epo)134.3LCPjr}
• Allele Name: transgene insertion 134.3 LC, Peter J Ratcliffe
• Allele ID: MGI:3767166
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epo^Tg(TAg/Epo)134.3LCPjr/Epo^Tg(TAg/Epo)134.3LCPjr	(C57BL/10 x CBA)F1 X CFLP	MGI:3767175
hm2	Epo^Tg(TAg/Epo)134.3LCPjr/Epo^Tg(TAg/Epo)134.3LCPjr	involves: C57BL/6 * CBA	MGI:3767176
ht3	Epo^Tg(TAg/Epo)134.3LCPjr/Epo^+	(C57BL/10 x CBA)F1 X CFLP	MGI:3767174
ht4	Epo^Tg(TAg/Epo)134.3LCPjr/Epo^+	involves: C57BL/6 * CBA	MGI:3767178

Genotype
MGI:3767175

hm1

• Allelic Composition: Epo^{Tg(TAg/Epo)134.3LCPjr}/Epo^{Tg(TAg/Epo)134.3LCPjr}
• Genetic Background: (C57BL/10 x CBA)F1 X CFLP

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

anemia ( J:128415 )

• mice have a 70% reduction in hemocrit values

Genotype
MGI:3767176

hm2

• Allelic Composition: Epo^{Tg(TAg/Epo)134.3LCPjr}/Epo^{Tg(TAg/Epo)134.3LCPjr}
• Genetic Background: involves: C57BL/6 * CBA

hematopoietic system

increased spleen weight ( J:79374 )

• six fold increase in spleen weight

anemia ( J:79374 , J:128248 )

• mice have a 66% reduction in hemocrit values (J:79374)

• mice have a 60% reduction in hemocrit values (J:128248)

homeostasis/metabolism

decreased oxygen consumption ( J:128248 )

• maximum oxygen consumption is reduced by 30%

hyperoxia ( J:128248 )

• 11% increase in arterial partial O2 levels compared to wild-type mice

hypoxia ( J:79374 )

• hypoxia occurs in hindlimb skeletal muscle as determined by increased CD31 and VEGF expression

hemosiderosis ( J:79374 )

• livers show an increase in the amount of nonheme iron in the cytoplasm of the Kupffer and parenchymal cells

cardiovascular system

increased myocardial fiber size ( J:79374 )

• 20% increase in the length of the sarcomeres

increased heart weight ( J:79374 )

• two fold increase in heart weight that is consistent with anemia-associated hypertrophy

increased heart left ventricle weight ( J:128248 )

• 27% increase in weight

increased heart right ventricle weight ( J:128242 , J:128248 )

• no further increases in weight occur when mice are hypoxic for 2 weeks (J:128242)

• 44% average increase in weight (J:128248)

muscle

increased myocardial fiber size ( J:79374 )

• 20% increase in the length of the sarcomeres

immune system

increased spleen weight ( J:79374 )

• six fold increase in spleen weight

respiratory system

increased pulmonary ventilation ( J:128242 , J:128248 )

• mice increase their ventilation with acclimatization to hypoxia (J:128242)

• ventilation under normoxia conditions is increased almost 1.7 fold due to larger tidal volumes of each respiration (J:128248)

hyperventilation ( J:128248 )

• mice have an increased respiratory rate when subjected to hypoxic conditions

growth/size/body

increased heart weight ( J:79374 )

• two fold increase in heart weight that is consistent with anemia-associated hypertrophy

increased spleen weight ( J:79374 )

• six fold increase in spleen weight

Genotype
MGI:3767174

ht3

• Allelic Composition: Epo^{Tg(TAg/Epo)134.3LCPjr}/Epo⁺
• Genetic Background: (C57BL/10 x CBA)F1 X CFLP

hematopoietic system

anemia ( J:128415 )

• mice have a 25% reduction in hemocrit values

Genotype
MGI:3767178

ht4

• Allelic Composition: Epo^{Tg(TAg/Epo)134.3LCPjr}/Epo⁺
• Genetic Background: involves: C57BL/6 * CBA

hematopoietic system

anemia ( J:79374 )

• mice have a 32% reduction in hemocrit values