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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabrb3tm2.2Geh
targeted mutation 2.2, Gregg E Homanics
MGI:3767251
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabrb3tm2.2Geh/Gabrb3tm2.2Geh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:3767260


Genotype
MGI:3767260
hm1
Allelic
Composition		 Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrb3tm2.2Geh mutation (0 available); any Gabrb3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:127877 )
• single surviving offspring (1 out of 11) died at day 21
neonatal lethality, incomplete penetrance ( J:127877 )
• while the frequency of homozygous mutant offspring was close to the expected Mendelian ratio, most of off live offspring died 2 days postnatally

craniofacial
cleft palate ( J:127877 )
• 54% (6 of 11) had cleft palate

digestive/alimentary system
cleft palate ( J:127877 )
• 54% (6 of 11) had cleft palate

growth/size/body
cleft palate ( J:127877 )
• 54% (6 of 11) had cleft palate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory