Phenotypes associated with this allele

• Allele Symbol: Tg(Nes-cre/ERT2)KEisc
• Allele Name: transgene insertion K, Amelia Eisch
• Allele ID: MGI:3767432
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tet1^tm1Gxu/Tet1^tm1.1Gxu Tg(Nes-cre/ERT2)KEisc/0	involves: 129 * C57BL/6J	MGI:5523877
cn2	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^+ Rest^tm1.1Jhsi/Rest^tm1.1Jhsi Tg(Nes-cre/ERT2)KEisc/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	MGI:5141116

Genotype
MGI:5523877

cn1

• Allelic Composition: Tet1^tm1Gxu/Tet1^tm1.1Gxu; Tg(Nes-cre/ERT2)KEisc/0
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice

abnormal neuronal precursor proliferation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

cellular

abnormal neuron differentiation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice

abnormal neuronal precursor proliferation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

Genotype
MGI:5141116

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Rest^tm1.1Jhsi/Rest^tm1.1Jhsi; Tg(Nes-cre/ERT2)KEisc/0
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

nervous system

abnormal neuron differentiation ( J:174056 )

• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice

• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls

• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice

• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice

• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells

• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment

premature neuronal precursor differentiation ( J:174056 )

• in tamoxifen-treated mice

decreased neuron number ( J:174056 )

• tamoxifen-treated mice exhibit decreased adult-generated immature and mature granule neurons compared with control mice

cellular

abnormal neuron differentiation ( J:174056 )

• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice

• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls

• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice

• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice

• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells

• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment

premature neuronal precursor differentiation ( J:174056 )

• in tamoxifen-treated mice