Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-EGFP-CAT-DTA)2Masa
• Allele Name: transgene insertion 2, Masahiro Sato
• Allele ID: MGI:3767445
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Etl4^tm1(cre)Kymm/Etl4^+ Tg(CAG-EGFP-CAT-DTA)2Masa/0	involves: C3H * C57BL/6NCrlj * CBA/JNCrlj	MGI:5436107
cx2	Tg(CAG-EGFP-CAT-DTA)2Masa/? Tg(Mbp-cre,CAG-EGFP)53Masa/?	involves: C3H * C3H/HeN * C57BL/6 * C57BL/6N	MGI:3767447

Genotype
MGI:5436107

cn1

• Allelic Composition: Etl4^tm1(cre)Kymm/Etl4⁺; Tg(CAG-EGFP-CAT-DTA)2Masa/0
• Genetic Background: involves: C3H * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality ( J:187217 )

• only 2/58 double mutant offspring are identified from crosses of cre-expressing mice with DTA-transgenic mice

skeleton

abnormal nucleus pulposus morphology ( J:187217 )

• at 8 weeks, histological analyses of caudal intervertebral disks show reductions of Safranin O-positive nucleus pulposus cells compared to wild-type

behavior/neurological

behavior/neurological phenotype ( J:187217 )

N • double mutants display no gait or behavioral abnormalities through sexual maturation

Genotype
MGI:3767447

cx2

• Allelic Composition: Tg(CAG-EGFP-CAT-DTA)2Masa/?; Tg(Mbp-cre,CAG-EGFP)53Masa/?
• Genetic Background: involves: C3H * C3H/HeN * C57BL/6 * C57BL/6N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:128247 )

• while embryos are present at E9.5 none remain alive at E11.5

embryo

decreased embryo size ( J:128247 )

• at E 9.5 some embryos are small

growth/size/body

decreased embryo size ( J:128247 )

• at E 9.5 some embryos are small