Phenotypes associated with this allele

• Allele Symbol: Cdkn2b^tm2Brn
• Allele Name: targeted mutation 2, Anton Berns
• Allele ID: MGI:3767459
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Cdkn2b^tm2Brn/Cdkn2b^tm2Brn	involves: 129P2/OlaHsd * FVB/N	MGI:3766049

Genotype
MGI:3766049

cx1

• Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn; Cdkn2b^tm2Brn/Cdkn2b^tm2Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:125189 )

N • untreated mice do not show any increased susceptibility to tumor formation within the first year

increased incidence of tumors by chemical induction ( J:125189 )

• treatment of newborns with dimethylbenzantrene (DMBA) induces the same tumors as observed in Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Cdkn2b^tm1Brn/Cdkn2b^tm1Brn Tg(ACTB-cre)2Mrt mice

• DMBA-induced tumors occur earlier and exhibit a much broader diversity than those that develop in DMBA treated Cdkn2a^tm1.1Brn homozygotes

increased skin tumor incidence ( J:125189 )

• treatment of newborns with dimethylbenzantrene (DMBA) induces skin tumors

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:125189 )

• treatment of newborns with dimethylbenzantrene (DMBA) induces the same tumors as observed in Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Cdkn2b^tm1Brn/Cdkn2b^tm1Brn Tg(ACTB-cre)2Mrt mice

• DMBA-induced tumors occur earlier and exhibit a much broader diversity than those that develop in DMBA treated Cdkn2a^tm1.1Brn homozygotes

integument

increased skin tumor incidence ( J:125189 )

• treatment of newborns with dimethylbenzantrene (DMBA) induces skin tumors