Analysis Tools|
Allele Symbol Allele Name Allele ID |
Del(4Cdkn2a-Cdkn2b)2Brn deletion, Chr 4, Anton Berns 2 MGI:3767464 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• except for skin tumors mice develop similar tumors as homozygous animals
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• mice develop similar tumors as homozygous animals but with much longer latency
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• within 7 months mice develop one or more tumors
• tumors are often composed of different cell types and frequently show biphasic morphology
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• a few mice develop adenocarcinoma of the intestinal tract
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• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors
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• several mice develop lymphoma and leukemia
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• several mice develop lymphoma and leukemia
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• one mouse develops spontaneous melanoma at 3 weeks of age
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• within 7 months mice develop one or more tumor including various soft tissue sarcomas
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• within 7 months mice develop one or more tumor that are predominantly skin tumor such as squamous cell carcinoma, basal cell carcinoma and tricho-epithelioma/hair-germ-cell tumors
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• a few mice develop adenocarcinoma of the intestinal tract
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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