Phenotypes associated with this allele

• Allele Symbol: Actn4^tm1.1Mrpk
• Allele Name: targeted mutation 1.1, Martin R Pollak
• Allele ID: MGI:3767564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actn4^tm1.1Mrpk/Actn4^tm1.1Mrpk	involves: 129S4/SvJae * 129X1/SvJ	MGI:3767568

Genotype
MGI:3767568

hm1

• Allelic Composition: Actn4^tm1.1Mrpk/Actn4^tm1.1Mrpk
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal renal glomerulus podocyte morphology in Actn4^tm1.1Mrpk/Actn4^tm1.1Mrpk mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:90755 )

• fewer numbers (10% instead of 25%) than expected are seen at weaning, indicating increased peri- or neonatal lethality

renal/urinary system

increased urine protein level ( J:90755 )

abnormal podocyte morphology ( J:90755 )

• abnormal electron-dense structures are seen in podocyte cell bodies

podocyte foot process effacement ( J:90755 )

• kidneys exhibit abnormalities in podocyte structure consisting of focal areas of foot process effacement

abnormal renal glomerulus morphology ( J:90755 )

homeostasis/metabolism

increased urine protein level ( J:90755 )