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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9M2Btlr
mutation 2, Bruce Beutler
MGI:3767565
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr9M2Btlr/Tlr9M2Btlr C57BL/6J-Tlr9M2Btlr MGI:3767569
ht2
 		Tlr9M2Btlr/Tlr9+ C57BL/6J-Tlr9M2Btlr MGI:3767573


Genotype
MGI:3767569
hm1
Allelic
Composition		 Tlr9M2Btlr/Tlr9M2Btlr
Genetic
Background		 C57BL/6J-Tlr9M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M2Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:128405 )
• peritoneal macrophages of homozygous mutant mice fail to produce tumor necrosis factor (TNF-) alpha in response to oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs)
• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), lipopolysaccharide (LPS, a TLR4 ligand), and R-848 (resiquimod, a single-stranded RNA mimetic and TLR7 ligand)
increased susceptibility to Herpesvirales infection ( J:128405 )
• homozygous mutant mice died within 6 days after infection with a normally sublethal inoculum (1 x 105 CFU) of mouse cytomegalovirus (MCMV), while infected wild-type mice showed no sign of sickness

hematopoietic system
abnormal macrophage physiology ( J:128405 )
• peritoneal macrophages of homozygous mutant mice fail to produce tumor necrosis factor (TNF-) alpha in response to oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs)
• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), lipopolysaccharide (LPS, a TLR4 ligand), and R-848 (resiquimod, a single-stranded RNA mimetic and TLR7 ligand)




Genotype
MGI:3767573
ht2
Allelic
Composition		 Tlr9M2Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M2Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:128405 )
• in response to CpG ODN, macrophages from mice heterozygous for the Cpg2 mutation produce an amount of TNF-alpha intermediate between homozygous mutant and wild-type levels

hematopoietic system
abnormal macrophage physiology ( J:128405 )
• in response to CpG ODN, macrophages from mice heterozygous for the Cpg2 mutation produce an amount of TNF-alpha intermediate between homozygous mutant and wild-type levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory