Phenotypes associated with this allele

• Allele Symbol: Tlr9^m3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:3767571
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr9^m3Btlr/Tlr9^m3Btlr	C57BL/6J-Tlr9^m3Btlr	MGI:3767572

Genotype
MGI:3767572

hm1

• Allelic Composition: Tlr9^m3Btlr/Tlr9^m3Btlr
• Genetic Background: C57BL/6J-Tlr9^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:128406 )

• naive B cells from peripheral blood of homozygous CpG3 mutant mice fail to proliferate upon stimulation with oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) in vitro, a response specific for CpG ODNs among other Toll-like receptor (TLR) agonists

abnormal macrophage physiology ( J:128406 )

• peritoneal macrophages from homozygous mutant mice produce no tumor necrosis factor (TNF-) alpha in response to oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs)

• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), lipopolysaccharide (LPS, a TLR4 ligand), and R-848 (resiquimod, a single-stranded RNA mimetic and TLR7 ligand)

hematopoietic system

decreased B cell proliferation ( J:128406 )

• naive B cells from peripheral blood of homozygous CpG3 mutant mice fail to proliferate upon stimulation with oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) in vitro, a response specific for CpG ODNs among other Toll-like receptor (TLR) agonists

abnormal macrophage physiology ( J:128406 )

• peritoneal macrophages from homozygous mutant mice produce no tumor necrosis factor (TNF-) alpha in response to oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs)

• TNF-alpha production by homozygous mutant macrophages is normal following stimulation with MALP-2 (macrophage-activating lipopeptide-2, a TLR2/6 ligand), Pam3CSK4 (a triacyl lipopeptide and TLR2/1 ligand), poly I:C (a TLR3 ligand), lipopolysaccharide (LPS, a TLR4 ligand), and R-848 (resiquimod, a single-stranded RNA mimetic and TLR7 ligand)

cellular

decreased B cell proliferation ( J:128406 )

• naive B cells from peripheral blood of homozygous CpG3 mutant mice fail to proliferate upon stimulation with oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) in vitro, a response specific for CpG ODNs among other Toll-like receptor (TLR) agonists